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- W4313367891 abstract "Gelatin, being a naturally derived biomacromolecule shows good biocompatibility and biodegradability and hence turn out to be a potential biomaterial in synthesizing adhesive hydrogel. However, to achieve significant adhesive strength under wet condition and good mechanical properties, gelatin is functionalised with dopamine and acrylic acid. Here, inspired from nature, we have developed a gelatin based adhesive hydrogel for wet surfaces by incorporating dopamine into gelatin-poly(acrylic acid) chain. The synthesized hydrogel demonstrate good mechanical strength, high stretchability, reversibility, self-healing and dynamic adhesive behaviour along with long term reusability. The adhesive strength of the synthesized hydrogel to tissue surface was found to be 6.5 KPa when applied under submerged condition. Moreover, the swelling behaviour of the hydrogel reveals that hydrogel have limited swellability thereby retaining adhesive property under fully swollen state. Haemolysis results reveals the biocompatible nature of the hydrogel. Thus this hydrogel emerge to be a promising bioadhesive for application in various fields mostly in biomedical devices." @default.
- W4313367891 created "2023-01-06" @default.
- W4313367891 creator A5002905116 @default.
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- W4313367891 date "2023-02-01" @default.
- W4313367891 modified "2023-09-30" @default.
- W4313367891 title "Development of mussel mimetic gelatin based adhesive hydrogel for wet surfaces with self-healing and reversible properties" @default.
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- W4313367891 doi "https://doi.org/10.1016/j.ijbiomac.2022.12.151" @default.
- W4313367891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36566806" @default.
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