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- W4313367918 abstract "In the last two years, the world encountered the SARS-CoV-2 virus, which is still dominating the population due to the absence of a viable treatment. To eradicate the global pandemic, scientists, doctors, and researchers took an exceptionally significant initiative towards the development of effective therapeutics to save many lifes. This review discusses about the single-domain antibodies (sdAbs), also called nanobodies, their structure, and their types against the infections of dreadful SARS-CoV-2 virus. A precise description highlights the nanobodies and their therapeutic application against the other selected viruses. It aims to focus on the extraordinary features of these antibodies compared to the conventional therapeutics like mAbs, convalescent plasma therapy, and vaccines. The stable structure of these nanobodies along with the suitable mechanism of action also confers greater resistance to the evolving variants with numerous mutations. The nanobodies developed against SARS-CoV-2 and its mutant variants have shown the greater neutralization potential than the primitive ones. Engineering of these specialized antibodies by modern biotechnological approaches will surely be more beneficial in treating this COVID-19 pandemic along with certain other viral infections." @default.
- W4313367918 created "2023-01-06" @default.
- W4313367918 creator A5001497588 @default.
- W4313367918 creator A5020432140 @default.
- W4313367918 creator A5037330858 @default.
- W4313367918 creator A5056540491 @default.
- W4313367918 date "2023-02-01" @default.
- W4313367918 modified "2023-10-06" @default.
- W4313367918 title "Therapeutic applications of nanobodies against SARS-CoV-2 and other viral infections: Current update" @default.
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- W4313367918 doi "https://doi.org/10.1016/j.ijbiomac.2022.12.284" @default.
- W4313367918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36586649" @default.
- W4313367918 hasPublicationYear "2023" @default.
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