FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313368059> ?p ?o ?g. }

• W4313368059 endingPage "110333" @default.
• W4313368059 startingPage "110333" @default.
• W4313368059 abstract "Visceral leishmaniasis (VL) is a progressive, debilitating, and potentially fatal disease if left untreated. As a neglected tropical disease (NTD), the available treatment is restricted to a few drugs, which typically must be administered over a long period but are associated with serious adverse effects and have variability in efficacy. In this sense, drug repositioning has been considered an excellent strategy in the search for alternative treatments, especially in reducing the time and cost of the research. In this work, the repositioning potential of amodiaquine (AQ), a well-known antimalarial drug, was investigated for the treatment of VL. AQ showed significant and selective activity against promastigotes (IC50 = 11.6 μg/mL) and intracellular amastigotes (IC50 = 2.4 μg/mL) of L. infantum, being 10 times more destructive to the intracellular parasites than the host cell. In addition, pre-treatment of macrophages with AQ caused a significant reduction in the infection index, indicating a prophylactic effect of this drug. SEM images showed that AQ induces strong shape alterations of the promastigotes with an increase in cell volume with rounding and ribbing (vertical ridges), as well as a shortened flagellum. In addition, AQ induced depolarization of the ΔΨm, an increase in ROS and neutral lipids levels, and changes in the cell cycle in promastigotes, without alterations to the permeability of the parasite plasma membrane. L. infantum-infected macrophages treated with AQ induced the activation of oxidative mechanisms by infected host cells, with an increase in ROS and NO levels. Finally, in vitro interactions between AQ and miltefosine were found to have an additive effect in both biological stages of the parasite, with the ∑FIC50 values ranging from 0.74 to 1.16 μg/mL and 0.54-1.11 μg/mL for promastigotes and intracellular amastigotes, respectively. Overall, these data highlight the utility of drug repurposing and indicate future preclinical testing for AQ itself or in combination as a potential VL treatment." @default.
• W4313368059 created "2023-01-06" @default.
• W4313368059 creator A5004186726 @default.
• W4313368059 creator A5006666942 @default.
• W4313368059 creator A5030224825 @default.
• W4313368059 creator A5060050502 @default.
• W4313368059 creator A5067888096 @default.
• W4313368059 creator A5086284068 @default.
• W4313368059 date "2023-02-01" @default.
• W4313368059 modified "2023-10-08" @default.
• W4313368059 title "Exploring the repositioning of the amodiaquine as potential drug against visceral leishmaniasis: The in vitro effect against Leishmania infantum is associated with multiple mechanisms, involving mitochondria dysfunction, oxidative stress and loss of cell cycle control" @default.
• W4313368059 cites W1990347765 @default.
• W4313368059 cites W1999311621 @default.
• W4313368059 cites W2001645914 @default.
• W4313368059 cites W2016562927 @default.
• W4313368059 cites W2026269205 @default.
• W4313368059 cites W2057499586 @default.
• W4313368059 cites W2087093746 @default.
• W4313368059 cites W2093460464 @default.
• W4313368059 cites W2115877902 @default.
• W4313368059 cites W2119993161 @default.
• W4313368059 cites W2122516779 @default.
• W4313368059 cites W2146071910 @default.
• W4313368059 cites W2154316070 @default.
• W4313368059 cites W2338568170 @default.
• W4313368059 cites W2399140686 @default.
• W4313368059 cites W2571341150 @default.
• W4313368059 cites W2595618202 @default.
• W4313368059 cites W2737879468 @default.
• W4313368059 cites W2783069166 @default.
• W4313368059 cites W2801705253 @default.
• W4313368059 cites W2887791042 @default.
• W4313368059 cites W2890349729 @default.
• W4313368059 cites W2898847553 @default.
• W4313368059 cites W2899491044 @default.
• W4313368059 cites W2970341349 @default.
• W4313368059 cites W2979847526 @default.
• W4313368059 cites W2980982965 @default.
• W4313368059 cites W2982420026 @default.
• W4313368059 cites W2984238269 @default.
• W4313368059 cites W3082435589 @default.
• W4313368059 cites W3084158514 @default.
• W4313368059 cites W3187318779 @default.
• W4313368059 cites W3207330473 @default.
• W4313368059 cites W4211073781 @default.
• W4313368059 cites W4213166584 @default.
• W4313368059 cites W4220925602 @default.
• W4313368059 cites W4224240577 @default.
• W4313368059 cites W4281566694 @default.
• W4313368059 doi "https://doi.org/10.1016/j.cbi.2022.110333" @default.
• W4313368059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36592711" @default.
• W4313368059 hasPublicationYear "2023" @default.
• W4313368059 type Work @default.
• W4313368059 citedByCount "0" @default.
• W4313368059 crossrefType "journal-article" @default.
• W4313368059 hasAuthorship W4313368059A5004186726 @default.
• W4313368059 hasAuthorship W4313368059A5006666942 @default.
• W4313368059 hasAuthorship W4313368059A5030224825 @default.
• W4313368059 hasAuthorship W4313368059A5060050502 @default.
• W4313368059 hasAuthorship W4313368059A5067888096 @default.
• W4313368059 hasAuthorship W4313368059A5086284068 @default.
• W4313368059 hasConcept C136764020 @default.
• W4313368059 hasConcept C185592680 @default.
• W4313368059 hasConcept C203014093 @default.
• W4313368059 hasConcept C2776151105 @default.
• W4313368059 hasConcept C2776555147 @default.
• W4313368059 hasConcept C2776992834 @default.
• W4313368059 hasConcept C2778048844 @default.
• W4313368059 hasConcept C2778371730 @default.
• W4313368059 hasConcept C2778689377 @default.
• W4313368059 hasConcept C2781092759 @default.
• W4313368059 hasConcept C2781257258 @default.
• W4313368059 hasConcept C2781417161 @default.
• W4313368059 hasConcept C41008148 @default.
• W4313368059 hasConcept C55493867 @default.
• W4313368059 hasConcept C71928629 @default.
• W4313368059 hasConcept C79879829 @default.
• W4313368059 hasConcept C86803240 @default.
• W4313368059 hasConcept C98274493 @default.
• W4313368059 hasConcept C98319499 @default.
• W4313368059 hasConceptScore W4313368059C136764020 @default.
• W4313368059 hasConceptScore W4313368059C185592680 @default.
• W4313368059 hasConceptScore W4313368059C203014093 @default.
• W4313368059 hasConceptScore W4313368059C2776151105 @default.
• W4313368059 hasConceptScore W4313368059C2776555147 @default.
• W4313368059 hasConceptScore W4313368059C2776992834 @default.
• W4313368059 hasConceptScore W4313368059C2778048844 @default.
• W4313368059 hasConceptScore W4313368059C2778371730 @default.
• W4313368059 hasConceptScore W4313368059C2778689377 @default.
• W4313368059 hasConceptScore W4313368059C2781092759 @default.
• W4313368059 hasConceptScore W4313368059C2781257258 @default.
• W4313368059 hasConceptScore W4313368059C2781417161 @default.
• W4313368059 hasConceptScore W4313368059C41008148 @default.
• W4313368059 hasConceptScore W4313368059C55493867 @default.
• W4313368059 hasConceptScore W4313368059C71928629 @default.
• W4313368059 hasConceptScore W4313368059C79879829 @default.
• W4313368059 hasConceptScore W4313368059C86803240 @default.
• W4313368059 hasConceptScore W4313368059C98274493 @default.

• next