Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313368323> ?p ?o ?g. }
- W4313368323 endingPage "111905" @default.
- W4313368323 startingPage "111905" @default.
- W4313368323 abstract "While cytoplasmic tryptophanyl-tRNA synthetase (WARS1) ligates tryptophan (Trp) to its cognate tRNAs for protein synthesis, it also plays a role as an innate immune activator in extracellular space. However, its secretion mechanism remains elusive. Here, we report that in response to stimuli, WARS1 can be secreted via two distinct pathways: via Trp-dependent secretion of naked protein and via Trp-independent plasma-membrane-derived vesicles (PMVs). In the direct pathway, Trp binding to WARS1 induces a “closed” conformation, generating a hydrophobic surface and basic pocket. The Trp-bound WARS1 then binds stable phosphatidylinositol (4,5)-biphosphate and inner plasma membrane leaflet, passing across the membrane. In the PMV-mediated secretion, WARS1 recruits calpain 2, which is activated by calcium. WARS1 released from PMVs induces inflammatory responses in vivo. These results provide insights into the secretion mechanisms of WARS1 and improve our understanding of how WARS1 is involved in the control of local and systemic inflammation upon infection." @default.
- W4313368323 created "2023-01-06" @default.
- W4313368323 creator A5009313361 @default.
- W4313368323 creator A5020995246 @default.
- W4313368323 creator A5022495972 @default.
- W4313368323 creator A5023304720 @default.
- W4313368323 creator A5030309363 @default.
- W4313368323 creator A5050008313 @default.
- W4313368323 creator A5050662142 @default.
- W4313368323 creator A5060550819 @default.
- W4313368323 creator A5069167592 @default.
- W4313368323 creator A5069709090 @default.
- W4313368323 creator A5088774065 @default.
- W4313368323 date "2023-01-01" @default.
- W4313368323 modified "2023-09-29" @default.
- W4313368323 title "Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses" @default.
- W4313368323 cites W1489489167 @default.
- W4313368323 cites W1651376769 @default.
- W4313368323 cites W1985764146 @default.
- W4313368323 cites W1986321004 @default.
- W4313368323 cites W1995622771 @default.
- W4313368323 cites W2001842045 @default.
- W4313368323 cites W2010625319 @default.
- W4313368323 cites W2029955024 @default.
- W4313368323 cites W2052423528 @default.
- W4313368323 cites W2065635384 @default.
- W4313368323 cites W2071517838 @default.
- W4313368323 cites W2075286609 @default.
- W4313368323 cites W2086275775 @default.
- W4313368323 cites W2091648834 @default.
- W4313368323 cites W2100999725 @default.
- W4313368323 cites W2113901436 @default.
- W4313368323 cites W2121725913 @default.
- W4313368323 cites W2142520482 @default.
- W4313368323 cites W2142788310 @default.
- W4313368323 cites W2144234841 @default.
- W4313368323 cites W2147546596 @default.
- W4313368323 cites W2149604782 @default.
- W4313368323 cites W2151078743 @default.
- W4313368323 cites W2164819852 @default.
- W4313368323 cites W2173662594 @default.
- W4313368323 cites W2522054313 @default.
- W4313368323 cites W2522681982 @default.
- W4313368323 cites W2536301196 @default.
- W4313368323 cites W2537845836 @default.
- W4313368323 cites W2566427422 @default.
- W4313368323 cites W2625552877 @default.
- W4313368323 cites W2800982196 @default.
- W4313368323 cites W2801400510 @default.
- W4313368323 cites W2805608765 @default.
- W4313368323 cites W2898591372 @default.
- W4313368323 cites W2944096460 @default.
- W4313368323 cites W3034010329 @default.
- W4313368323 cites W3083343427 @default.
- W4313368323 cites W3093868490 @default.
- W4313368323 cites W3199270059 @default.
- W4313368323 doi "https://doi.org/10.1016/j.celrep.2022.111905" @default.
- W4313368323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640342" @default.
- W4313368323 hasPublicationYear "2023" @default.
- W4313368323 type Work @default.
- W4313368323 citedByCount "0" @default.
- W4313368323 crossrefType "journal-article" @default.
- W4313368323 hasAuthorship W4313368323A5009313361 @default.
- W4313368323 hasAuthorship W4313368323A5020995246 @default.
- W4313368323 hasAuthorship W4313368323A5022495972 @default.
- W4313368323 hasAuthorship W4313368323A5023304720 @default.
- W4313368323 hasAuthorship W4313368323A5030309363 @default.
- W4313368323 hasAuthorship W4313368323A5050008313 @default.
- W4313368323 hasAuthorship W4313368323A5050662142 @default.
- W4313368323 hasAuthorship W4313368323A5060550819 @default.
- W4313368323 hasAuthorship W4313368323A5069167592 @default.
- W4313368323 hasAuthorship W4313368323A5069709090 @default.
- W4313368323 hasAuthorship W4313368323A5088774065 @default.
- W4313368323 hasBestOaLocation W43133683231 @default.
- W4313368323 hasConcept C136449434 @default.
- W4313368323 hasConcept C170493617 @default.
- W4313368323 hasConcept C185592680 @default.
- W4313368323 hasConcept C203014093 @default.
- W4313368323 hasConcept C2776706248 @default.
- W4313368323 hasConcept C2776914184 @default.
- W4313368323 hasConcept C49039625 @default.
- W4313368323 hasConcept C515207424 @default.
- W4313368323 hasConcept C55493867 @default.
- W4313368323 hasConcept C86803240 @default.
- W4313368323 hasConcept C95444343 @default.
- W4313368323 hasConceptScore W4313368323C136449434 @default.
- W4313368323 hasConceptScore W4313368323C170493617 @default.
- W4313368323 hasConceptScore W4313368323C185592680 @default.
- W4313368323 hasConceptScore W4313368323C203014093 @default.
- W4313368323 hasConceptScore W4313368323C2776706248 @default.
- W4313368323 hasConceptScore W4313368323C2776914184 @default.
- W4313368323 hasConceptScore W4313368323C49039625 @default.
- W4313368323 hasConceptScore W4313368323C515207424 @default.
- W4313368323 hasConceptScore W4313368323C55493867 @default.
- W4313368323 hasConceptScore W4313368323C86803240 @default.
- W4313368323 hasConceptScore W4313368323C95444343 @default.
- W4313368323 hasIssue "1" @default.
- W4313368323 hasLocation W43133683231 @default.