Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313368415> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313368415 endingPage "243.18" @default.
- W4313368415 startingPage "243.18" @default.
- W4313368415 abstract "Abstract Loss of surface MHC I is an important mechanism by which cancer cells evade immune surveillance, and it can correlate with worse prognosis and resistance to immunotherapy. MHC I surface expression can be affected by genomic or transcriptional alterations to HLA-A/B/C, β2M, or the class I antigen processing machinery. In the case of transcriptional loss, we hypothesized that certain cancers might employ specific epigenetic programs to enforce downregulation of the MHC I pathway. Thus, we sought to identify novel MHC I regulators in MHC I-low cancers. In particular, we focused on Merkel cell carcinoma (MCC), a rare but aggressive neuroendocrine skin cancer that is caused by the Merkel cell polyomavirus in 80% of cases. Notably, MHC I downregulation is prevalent in MCC. We first generated and characterized a series of patient-derived MCC cell lines, in which MHC I surface expression was low but inducible with IFN-γ. We then conducted genome-scale CRISPR-KO and open reading frame (ORF) gain-of-function screens in one of our virus-positive MCC lines, using FACS to select for perturbations that upregulated surface MHC I. One of the top hits from these screens was PRC1.1, a non-canonical Polycomb repressive complex. Polycomb complexes are known to mediate gene silencing through chromatin modification and play an important role in development and cancer. These studies suggest a possible role for PRC1.1 in suppressing MHC I in MCC." @default.
- W4313368415 created "2023-01-06" @default.
- W4313368415 creator A5000801624 @default.
- W4313368415 creator A5005690333 @default.
- W4313368415 creator A5022151380 @default.
- W4313368415 creator A5047701430 @default.
- W4313368415 creator A5051881453 @default.
- W4313368415 creator A5054307336 @default.
- W4313368415 creator A5055361364 @default.
- W4313368415 creator A5081560191 @default.
- W4313368415 date "2020-05-01" @default.
- W4313368415 modified "2023-10-16" @default.
- W4313368415 title "Identifying regulators of reversible MHC I loss in Merkel cell carcinoma through genome-scale screens" @default.
- W4313368415 doi "https://doi.org/10.4049/jimmunol.204.supp.243.18" @default.
- W4313368415 hasPublicationYear "2020" @default.
- W4313368415 type Work @default.
- W4313368415 citedByCount "0" @default.
- W4313368415 crossrefType "journal-article" @default.
- W4313368415 hasAuthorship W4313368415A5000801624 @default.
- W4313368415 hasAuthorship W4313368415A5005690333 @default.
- W4313368415 hasAuthorship W4313368415A5022151380 @default.
- W4313368415 hasAuthorship W4313368415A5047701430 @default.
- W4313368415 hasAuthorship W4313368415A5051881453 @default.
- W4313368415 hasAuthorship W4313368415A5054307336 @default.
- W4313368415 hasAuthorship W4313368415A5055361364 @default.
- W4313368415 hasAuthorship W4313368415A5081560191 @default.
- W4313368415 hasConcept C104317684 @default.
- W4313368415 hasConcept C119056186 @default.
- W4313368415 hasConcept C121608353 @default.
- W4313368415 hasConcept C127561419 @default.
- W4313368415 hasConcept C170627219 @default.
- W4313368415 hasConcept C207936829 @default.
- W4313368415 hasConcept C2777546739 @default.
- W4313368415 hasConcept C2778342957 @default.
- W4313368415 hasConcept C41091548 @default.
- W4313368415 hasConcept C502942594 @default.
- W4313368415 hasConcept C54355233 @default.
- W4313368415 hasConcept C83640560 @default.
- W4313368415 hasConcept C86803240 @default.
- W4313368415 hasConcept C8891405 @default.
- W4313368415 hasConceptScore W4313368415C104317684 @default.
- W4313368415 hasConceptScore W4313368415C119056186 @default.
- W4313368415 hasConceptScore W4313368415C121608353 @default.
- W4313368415 hasConceptScore W4313368415C127561419 @default.
- W4313368415 hasConceptScore W4313368415C170627219 @default.
- W4313368415 hasConceptScore W4313368415C207936829 @default.
- W4313368415 hasConceptScore W4313368415C2777546739 @default.
- W4313368415 hasConceptScore W4313368415C2778342957 @default.
- W4313368415 hasConceptScore W4313368415C41091548 @default.
- W4313368415 hasConceptScore W4313368415C502942594 @default.
- W4313368415 hasConceptScore W4313368415C54355233 @default.
- W4313368415 hasConceptScore W4313368415C83640560 @default.
- W4313368415 hasConceptScore W4313368415C86803240 @default.
- W4313368415 hasConceptScore W4313368415C8891405 @default.
- W4313368415 hasIssue "1_Supplement" @default.
- W4313368415 hasLocation W43133684151 @default.
- W4313368415 hasOpenAccess W4313368415 @default.
- W4313368415 hasPrimaryLocation W43133684151 @default.
- W4313368415 hasRelatedWork W2041546512 @default.
- W4313368415 hasRelatedWork W2068062888 @default.
- W4313368415 hasRelatedWork W2086275191 @default.
- W4313368415 hasRelatedWork W2109763600 @default.
- W4313368415 hasRelatedWork W2604918044 @default.
- W4313368415 hasRelatedWork W3113327686 @default.
- W4313368415 hasRelatedWork W3134198332 @default.
- W4313368415 hasRelatedWork W4235079955 @default.
- W4313368415 hasRelatedWork W4362238417 @default.
- W4313368415 hasRelatedWork W4362545677 @default.
- W4313368415 hasVolume "204" @default.
- W4313368415 isParatext "false" @default.
- W4313368415 isRetracted "false" @default.
- W4313368415 workType "article" @default.