Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313368644> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4313368644 endingPage "231.7" @default.
- W4313368644 startingPage "231.7" @default.
- W4313368644 abstract "Abstract Pathogenic Escherichia coli strains remain a significant health challenge, particularly in developing countries. The social amoeba, Dictyostelium discoideum, which phagocytizes bacteria for nutritional purposes, serves as a host model for several pathogenic bacteria, including E. coli. Here we have characterized the interactions of D. discoideum with 35 representative E. coli strains and identified strains sensitive and resistant to D. discoideum grazing in each E. coli pathotype. Whole genome phylogenomic analysis revealed that grazing resistance is distributed among the phylotypes, although resistant strains are enriched in the B2 phylogenomic group. Comparative genomic analysis identified genes more prevalent among strains resistant to D. discoideum grazing, including genes associated with adhesion, carbohydrate modification, iron transport, signaling and metabolism. Interestingly, the gipA (growth in Peyer’s Patches) gene, which has been found associated with microbiota in patients with Crohn’s disease, was widely present in E. coli strains resistant for D. discoideum grazing. We are currently working to characterize the role of E. coli genes associated with resistance to phagocytosis and killing by D. discoideum, through creation and analysis of E. coli strains manipulated for expression of the identified genes. Such characterization is aimed at providing insight into potentially novel E. coli virulence factors." @default.
- W4313368644 created "2023-01-06" @default.
- W4313368644 creator A5001999510 @default.
- W4313368644 creator A5054727819 @default.
- W4313368644 creator A5071708917 @default.
- W4313368644 creator A5080577177 @default.
- W4313368644 date "2020-05-01" @default.
- W4313368644 modified "2023-10-14" @default.
- W4313368644 title "Identification and characterization of <i>Escherichia coli</i> genes associated with grazing resistance to the social amoeba <i>Dictyostelium discoideum</i>" @default.
- W4313368644 doi "https://doi.org/10.4049/jimmunol.204.supp.231.7" @default.
- W4313368644 hasPublicationYear "2020" @default.
- W4313368644 type Work @default.
- W4313368644 citedByCount "0" @default.
- W4313368644 crossrefType "journal-article" @default.
- W4313368644 hasAuthorship W4313368644A5001999510 @default.
- W4313368644 hasAuthorship W4313368644A5054727819 @default.
- W4313368644 hasAuthorship W4313368644A5071708917 @default.
- W4313368644 hasAuthorship W4313368644A5080577177 @default.
- W4313368644 hasConcept C104317684 @default.
- W4313368644 hasConcept C2775969001 @default.
- W4313368644 hasConcept C2776172558 @default.
- W4313368644 hasConcept C2779616913 @default.
- W4313368644 hasConcept C523546767 @default.
- W4313368644 hasConcept C54355233 @default.
- W4313368644 hasConcept C547475151 @default.
- W4313368644 hasConcept C60987743 @default.
- W4313368644 hasConcept C86803240 @default.
- W4313368644 hasConcept C89423630 @default.
- W4313368644 hasConceptScore W4313368644C104317684 @default.
- W4313368644 hasConceptScore W4313368644C2775969001 @default.
- W4313368644 hasConceptScore W4313368644C2776172558 @default.
- W4313368644 hasConceptScore W4313368644C2779616913 @default.
- W4313368644 hasConceptScore W4313368644C523546767 @default.
- W4313368644 hasConceptScore W4313368644C54355233 @default.
- W4313368644 hasConceptScore W4313368644C547475151 @default.
- W4313368644 hasConceptScore W4313368644C60987743 @default.
- W4313368644 hasConceptScore W4313368644C86803240 @default.
- W4313368644 hasConceptScore W4313368644C89423630 @default.
- W4313368644 hasIssue "1_Supplement" @default.
- W4313368644 hasLocation W43133686441 @default.
- W4313368644 hasOpenAccess W4313368644 @default.
- W4313368644 hasPrimaryLocation W43133686441 @default.
- W4313368644 hasRelatedWork W1985426194 @default.
- W4313368644 hasRelatedWork W1989838871 @default.
- W4313368644 hasRelatedWork W2061297944 @default.
- W4313368644 hasRelatedWork W2112175923 @default.
- W4313368644 hasRelatedWork W2159851879 @default.
- W4313368644 hasRelatedWork W2374660272 @default.
- W4313368644 hasRelatedWork W2805909579 @default.
- W4313368644 hasRelatedWork W2916250705 @default.
- W4313368644 hasRelatedWork W3112380051 @default.
- W4313368644 hasRelatedWork W3217740760 @default.
- W4313368644 hasVolume "204" @default.
- W4313368644 isParatext "false" @default.
- W4313368644 isRetracted "false" @default.
- W4313368644 workType "article" @default.