Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313368853> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313368853 endingPage "140.16" @default.
- W4313368853 startingPage "140.16" @default.
- W4313368853 abstract "Abstract T cells generate highly diverse T-cell receptors (TCRs) to recognize antigens, most of which are private to each individual. TCRs with low junctional complexity have a higher likelihood of being generated and shared across individuals. Additional factors that may further limit diversity and increase the likelihood that particular TCRs are public include: (a) thymus selection for maturation of TCRs that bind antigens presented by an individual’s human leukocyte antigen (HLA) proteins, and (b) T-cell proliferation upon exposure to cognate antigens, which remain in the periphery as memory T cells. Numerous public TCRs have been associated with particular HLA restrictions and antigen specificities1. Chowell et al. also showed that HLA diversity is important for mounting an effective T-cell response against solid tumors2. However, little is known about the impact of these forces on the diversity of the TCR repertoire and expected TCR sharing across individuals. Here, we leverage the TCR repertoires of 666 healthy individuals sequenced with the immunoSEQ® Assay (Adaptive Biotechnologies, Seattle, WA) to address these questions. We investigate (a) how HLA restriction affects immune repertoires by examining the effect of HLA heterozygosity and divergence on the diversity of the TCR repertoire; (b) how the similarity of HLA alleles between individuals impacts the number of TCRs shared between individuals and (c) the impact of shared antigen exposure by determining how age and CMV status impacts clone sharing between individuals. These data show that HLA type, age, and CMV exposure shape the immune repertoire and influence the sharing of clones between individuals." @default.
- W4313368853 created "2023-01-06" @default.
- W4313368853 creator A5010064754 @default.
- W4313368853 creator A5010753349 @default.
- W4313368853 creator A5015970952 @default.
- W4313368853 creator A5089581942 @default.
- W4313368853 date "2020-05-01" @default.
- W4313368853 modified "2023-10-16" @default.
- W4313368853 title "Determining the impact of HLA type and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals" @default.
- W4313368853 doi "https://doi.org/10.4049/jimmunol.204.supp.140.16" @default.
- W4313368853 hasPublicationYear "2020" @default.
- W4313368853 type Work @default.
- W4313368853 citedByCount "0" @default.
- W4313368853 crossrefType "journal-article" @default.
- W4313368853 hasAuthorship W4313368853A5010064754 @default.
- W4313368853 hasAuthorship W4313368853A5010753349 @default.
- W4313368853 hasAuthorship W4313368853A5015970952 @default.
- W4313368853 hasAuthorship W4313368853A5089581942 @default.
- W4313368853 hasConcept C104317684 @default.
- W4313368853 hasConcept C121332964 @default.
- W4313368853 hasConcept C147483822 @default.
- W4313368853 hasConcept C180754005 @default.
- W4313368853 hasConcept C188280979 @default.
- W4313368853 hasConcept C19317047 @default.
- W4313368853 hasConcept C203014093 @default.
- W4313368853 hasConcept C24890656 @default.
- W4313368853 hasConcept C2776090121 @default.
- W4313368853 hasConcept C2778473898 @default.
- W4313368853 hasConcept C54355233 @default.
- W4313368853 hasConcept C86803240 @default.
- W4313368853 hasConcept C8891405 @default.
- W4313368853 hasConceptScore W4313368853C104317684 @default.
- W4313368853 hasConceptScore W4313368853C121332964 @default.
- W4313368853 hasConceptScore W4313368853C147483822 @default.
- W4313368853 hasConceptScore W4313368853C180754005 @default.
- W4313368853 hasConceptScore W4313368853C188280979 @default.
- W4313368853 hasConceptScore W4313368853C19317047 @default.
- W4313368853 hasConceptScore W4313368853C203014093 @default.
- W4313368853 hasConceptScore W4313368853C24890656 @default.
- W4313368853 hasConceptScore W4313368853C2776090121 @default.
- W4313368853 hasConceptScore W4313368853C2778473898 @default.
- W4313368853 hasConceptScore W4313368853C54355233 @default.
- W4313368853 hasConceptScore W4313368853C86803240 @default.
- W4313368853 hasConceptScore W4313368853C8891405 @default.
- W4313368853 hasIssue "1_Supplement" @default.
- W4313368853 hasLocation W43133688531 @default.
- W4313368853 hasOpenAccess W4313368853 @default.
- W4313368853 hasPrimaryLocation W43133688531 @default.
- W4313368853 hasRelatedWork W1976217255 @default.
- W4313368853 hasRelatedWork W1989613103 @default.
- W4313368853 hasRelatedWork W1990329984 @default.
- W4313368853 hasRelatedWork W1991211153 @default.
- W4313368853 hasRelatedWork W2021502563 @default.
- W4313368853 hasRelatedWork W2057739827 @default.
- W4313368853 hasRelatedWork W2067167938 @default.
- W4313368853 hasRelatedWork W2091857464 @default.
- W4313368853 hasRelatedWork W2220102944 @default.
- W4313368853 hasRelatedWork W2540336298 @default.
- W4313368853 hasVolume "204" @default.
- W4313368853 isParatext "false" @default.
- W4313368853 isRetracted "false" @default.
- W4313368853 workType "article" @default.