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- W4313369023 abstract "Abstract Studying protein organization and function at molecular level is a major technical challenge that limits our understanding from both a diagnostic and treatment perspective. Single-molecule localization microscopy (SMLM) is a Nobel Prize winning technique that allows quantitative imaging below the diffraction limit and can be applied to significantly improve our understanding of many biological phenomena. We provide a versatile imaging platform with unrivalled stability and flexibility to work on a lab bench. The data presented was acquired using two and three-color, super-resolution imaging of EVs and TCR alpha and beta receptors and reveal their spatial organization at 20 nm resolution. Additional experiments to show levels of expression on the cell surface, yielding the characterization of receptor distribution and ultimately activity and signaling. Experiments will show the wide-ranging applicability of our instrument as a tool for multiple biological analyses encompassing many fields within immunology." @default.
- W4313369023 created "2023-01-06" @default.
- W4313369023 creator A5063736029 @default.
- W4313369023 date "2020-05-01" @default.
- W4313369023 modified "2023-09-25" @default.
- W4313369023 title "Gain a Better Understanding of Immunology using Single-Molecule Localization Microscopy" @default.
- W4313369023 doi "https://doi.org/10.4049/jimmunol.204.supp.159.48" @default.
- W4313369023 hasPublicationYear "2020" @default.
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