Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313369049> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4313369049 endingPage "226.32" @default.
- W4313369049 startingPage "226.32" @default.
- W4313369049 abstract "Abstract Toll-like receptors (TLRs) sense microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/Interleukin-1R homology (TIR) domain to initiate intracellular signaling. Activated TLRs dimerize their TIRs and recruit adapter proteins to the dimer, through multiple interactions of receptor and adapter TIR domains. Although TLRs play an essential role in innate immunity, the aberrant TLR signaling may cause pathogenic inflammation. This study has screened a library of cell-permeable decoy peptides (CPDPs) derived from the TLR7 TIR for interference with TLR7 signaling and identified several CPDPs that inhibit TLR7 signaling. Peptides 7R1, 7R6, 7R9 and 7R11 inhibited the TLR7-induced signaling in murine and human macrophages. The most potent inhibitory peptide of the four, 7R11, significantly reduced the systemic cytokine levels elicited by administration of a TLR7 agonist, R-848, to mice. TLR7 TIR surface regions that correspond to inhibitory peptides generally corresponded to four TIR sites that mediate signalosome assembly for other TLRs. The cell-based Förster resonance energy transfer/fluorescence lifetime imaging confirmed that 7R9 and 7R11 interact with adapter TIRs. These findings clarify the molecular mechanisms that trigger the adapter recruitment to activated TLR7 and suggest that 7R9 and 7R11 have a significant translational potential as candidate or lead therapeutics for treatment of TLR7-mediated inflammation." @default.
- W4313369049 created "2023-01-06" @default.
- W4313369049 creator A5071156187 @default.
- W4313369049 creator A5089218410 @default.
- W4313369049 date "2020-05-01" @default.
- W4313369049 modified "2023-09-27" @default.
- W4313369049 title "Targeting the TLR7 signalosome assembly by TLR7-derived decoy peptides" @default.
- W4313369049 doi "https://doi.org/10.4049/jimmunol.204.supp.226.32" @default.
- W4313369049 hasPublicationYear "2020" @default.
- W4313369049 type Work @default.
- W4313369049 citedByCount "0" @default.
- W4313369049 crossrefType "journal-article" @default.
- W4313369049 hasAuthorship W4313369049A5071156187 @default.
- W4313369049 hasAuthorship W4313369049A5089218410 @default.
- W4313369049 hasConcept C136449434 @default.
- W4313369049 hasConcept C170493617 @default.
- W4313369049 hasConcept C183786373 @default.
- W4313369049 hasConcept C2776709828 @default.
- W4313369049 hasConcept C2779836521 @default.
- W4313369049 hasConcept C55493867 @default.
- W4313369049 hasConcept C62478195 @default.
- W4313369049 hasConcept C86803240 @default.
- W4313369049 hasConcept C95444343 @default.
- W4313369049 hasConceptScore W4313369049C136449434 @default.
- W4313369049 hasConceptScore W4313369049C170493617 @default.
- W4313369049 hasConceptScore W4313369049C183786373 @default.
- W4313369049 hasConceptScore W4313369049C2776709828 @default.
- W4313369049 hasConceptScore W4313369049C2779836521 @default.
- W4313369049 hasConceptScore W4313369049C55493867 @default.
- W4313369049 hasConceptScore W4313369049C62478195 @default.
- W4313369049 hasConceptScore W4313369049C86803240 @default.
- W4313369049 hasConceptScore W4313369049C95444343 @default.
- W4313369049 hasIssue "1_Supplement" @default.
- W4313369049 hasLocation W43133690491 @default.
- W4313369049 hasOpenAccess W4313369049 @default.
- W4313369049 hasPrimaryLocation W43133690491 @default.
- W4313369049 hasRelatedWork W1988327539 @default.
- W4313369049 hasRelatedWork W2087494383 @default.
- W4313369049 hasRelatedWork W2093852189 @default.
- W4313369049 hasRelatedWork W2145019698 @default.
- W4313369049 hasRelatedWork W2359705949 @default.
- W4313369049 hasRelatedWork W2363770425 @default.
- W4313369049 hasRelatedWork W2410240262 @default.
- W4313369049 hasRelatedWork W3035787634 @default.
- W4313369049 hasRelatedWork W3117279292 @default.
- W4313369049 hasRelatedWork W4361189090 @default.
- W4313369049 hasVolume "204" @default.
- W4313369049 isParatext "false" @default.
- W4313369049 isRetracted "false" @default.
- W4313369049 workType "article" @default.