Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313369077> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313369077 endingPage "147.12" @default.
- W4313369077 startingPage "147.12" @default.
- W4313369077 abstract "Abstract Dendritic cells (DCs) are specialized antigen-presenting cells that play a crucial role in T helper (Th) cell differentiation. DCs of human airway comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs), of which the cDCs lineage consists of cDC type 1 (cDC1) and cDC type 2 (cDC2). These DCs subsets differ in ontogeny and functional properties in immune response. Thus, we aimed to evaluate the expression of different dendritic cell subsets in nasal mucosa of patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Nasal polyp tissues or ethmoid mucosa from patients undergoing endoscopic sinus surgery or septoplasty were collected. The expression of DCs was investigated by flow cytometry via surface markers including BDCA-1 (CD1c) for cDC1, BDCA-3 (CD141) for cDC2, and BDCA-2 (CD303) for pDC. In subjects with AR, BDCA-3+cDC levels significantly decreased in patients with accompanying CRS, more reduced in eosinophilic CRS (ECRS) than in non-eosinophilic CRS (NECRS), compared to non-CRS patients. In subjects with CRS, the expression of BDCA-3+cDC decreased in patients with accompanying AR; more reduced in multiple allergens sensitization. Consequently, the IF result showed CD4+ CD25+ Foxp3+ regulatory T cell expression was significantly decreased in CRS patients with AR compared to those without AR. Furthermore, the level of BDCA-3+cDC was also inversely related with preoperative CT scores, serum eosinophils and IgE levels. We suggest that BDCA-3+cDC may play an essential role in immunoregulation and induction of clinical tolerance. Reduced frequency of BDCA-3+cDC followed by impaired Treg expression in CRS patients with AR might reflect the mechanism of severe inflammation in patients of CRS combined with AR." @default.
- W4313369077 created "2023-01-06" @default.
- W4313369077 creator A5015023370 @default.
- W4313369077 creator A5024260561 @default.
- W4313369077 creator A5052205598 @default.
- W4313369077 creator A5059086827 @default.
- W4313369077 creator A5061877701 @default.
- W4313369077 date "2020-05-01" @default.
- W4313369077 modified "2023-09-27" @default.
- W4313369077 title "Reduced BDCA3+ dendritic cells in nasal mucosa induce severe inflammation in patients with allergic rhinitis and chronic rhinosinusitis" @default.
- W4313369077 doi "https://doi.org/10.4049/jimmunol.204.supp.147.12" @default.
- W4313369077 hasPublicationYear "2020" @default.
- W4313369077 type Work @default.
- W4313369077 citedByCount "0" @default.
- W4313369077 crossrefType "journal-article" @default.
- W4313369077 hasAuthorship W4313369077A5015023370 @default.
- W4313369077 hasAuthorship W4313369077A5024260561 @default.
- W4313369077 hasAuthorship W4313369077A5052205598 @default.
- W4313369077 hasAuthorship W4313369077A5059086827 @default.
- W4313369077 hasAuthorship W4313369077A5061877701 @default.
- W4313369077 hasConcept C105702510 @default.
- W4313369077 hasConcept C147483822 @default.
- W4313369077 hasConcept C203014093 @default.
- W4313369077 hasConcept C2776042228 @default.
- W4313369077 hasConcept C2776051438 @default.
- W4313369077 hasConcept C2776090121 @default.
- W4313369077 hasConcept C2777037409 @default.
- W4313369077 hasConcept C2777733662 @default.
- W4313369077 hasConcept C2778170410 @default.
- W4313369077 hasConcept C2778311950 @default.
- W4313369077 hasConcept C2779727006 @default.
- W4313369077 hasConcept C59377437 @default.
- W4313369077 hasConcept C71924100 @default.
- W4313369077 hasConcept C79484868 @default.
- W4313369077 hasConcept C8891405 @default.
- W4313369077 hasConceptScore W4313369077C105702510 @default.
- W4313369077 hasConceptScore W4313369077C147483822 @default.
- W4313369077 hasConceptScore W4313369077C203014093 @default.
- W4313369077 hasConceptScore W4313369077C2776042228 @default.
- W4313369077 hasConceptScore W4313369077C2776051438 @default.
- W4313369077 hasConceptScore W4313369077C2776090121 @default.
- W4313369077 hasConceptScore W4313369077C2777037409 @default.
- W4313369077 hasConceptScore W4313369077C2777733662 @default.
- W4313369077 hasConceptScore W4313369077C2778170410 @default.
- W4313369077 hasConceptScore W4313369077C2778311950 @default.
- W4313369077 hasConceptScore W4313369077C2779727006 @default.
- W4313369077 hasConceptScore W4313369077C59377437 @default.
- W4313369077 hasConceptScore W4313369077C71924100 @default.
- W4313369077 hasConceptScore W4313369077C79484868 @default.
- W4313369077 hasConceptScore W4313369077C8891405 @default.
- W4313369077 hasIssue "1_Supplement" @default.
- W4313369077 hasLocation W43133690771 @default.
- W4313369077 hasOpenAccess W4313369077 @default.
- W4313369077 hasPrimaryLocation W43133690771 @default.
- W4313369077 hasRelatedWork W1493798642 @default.
- W4313369077 hasRelatedWork W1505169546 @default.
- W4313369077 hasRelatedWork W1535737655 @default.
- W4313369077 hasRelatedWork W2036517776 @default.
- W4313369077 hasRelatedWork W2087165333 @default.
- W4313369077 hasRelatedWork W2289276257 @default.
- W4313369077 hasRelatedWork W2366649094 @default.
- W4313369077 hasRelatedWork W2765968104 @default.
- W4313369077 hasRelatedWork W2999733170 @default.
- W4313369077 hasRelatedWork W4313369077 @default.
- W4313369077 hasVolume "204" @default.
- W4313369077 isParatext "false" @default.
- W4313369077 isRetracted "false" @default.
- W4313369077 workType "article" @default.