Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313369080> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313369080 endingPage "68.22" @default.
- W4313369080 startingPage "68.22" @default.
- W4313369080 abstract "Abstract Atherosclerosis is an inflammatory disease of the arterial wall driven by macrophages and other immune cells. Olfactory receptors (Olfrs) are G-protein coupled receptors expressed in olfactory epithelium and are responsible for the sense of smell. We found that macrophages in the wall of atherosclerotic mouse aortas express some olfactory receptors including Olfr2, a specific receptor for an 8 carbon fatty-aldehyde called octanal. Octanal is detectable in food, mouse and human blood plasma, elevated by western diet, and partially derived from gut microbiota. Ligation of Olfr2 or its human orthologue OR6A2, expressed in human atherosclerotic plaque and in human monocyte-derived macrophages, is strongly pro-inflammatory, activates the NLRP3 inflammasome and, in synergy with LPS, induces secretion of IL-1β. Knockdown of Olfr2/OR6A2 in macrophages significantly reduced inflammatory cytokine secretion. To test the role of Olfr2 in atherosclerosis, we treated Apoe−/− mice with octanal or the Olfr2 antagonist citral. Octanal significantly exacerbated while citral significantly inhibited atherosclerosis. We generated Olfr2−/− mice by Crispr-Cas9. Ldlr−/− mice reconstituted with Olfr2−/− bone marrow developed ~50% smaller lesions on high cholesterol diet than littermate controls reconstituted with Olfr2+/+ bone marrow. Our findings suggest that small molecule inhibitors of Olfrs like OR6A2 are promising targets for drug development to prevent and treat atherosclerosis-based cardiovascular diseases." @default.
- W4313369080 created "2023-01-06" @default.
- W4313369080 creator A5001023635 @default.
- W4313369080 creator A5003355789 @default.
- W4313369080 creator A5006160939 @default.
- W4313369080 creator A5007202760 @default.
- W4313369080 creator A5023956402 @default.
- W4313369080 creator A5026259294 @default.
- W4313369080 creator A5028023818 @default.
- W4313369080 creator A5038247492 @default.
- W4313369080 creator A5040647937 @default.
- W4313369080 creator A5041756883 @default.
- W4313369080 creator A5052055498 @default.
- W4313369080 creator A5052827209 @default.
- W4313369080 creator A5053694276 @default.
- W4313369080 creator A5080013050 @default.
- W4313369080 creator A5080336977 @default.
- W4313369080 creator A5083751926 @default.
- W4313369080 creator A5086913810 @default.
- W4313369080 date "2020-05-01" @default.
- W4313369080 modified "2023-10-16" @default.
- W4313369080 title "Olfactory receptor 2 (Olfr2) and its human ortholog OR6A2 expressed in macrophages drive NLRP3 inflammasome activation and exacerbate atherosclerosis in mice" @default.
- W4313369080 doi "https://doi.org/10.4049/jimmunol.204.supp.68.22" @default.
- W4313369080 hasPublicationYear "2020" @default.
- W4313369080 type Work @default.
- W4313369080 citedByCount "0" @default.
- W4313369080 crossrefType "journal-article" @default.
- W4313369080 hasAuthorship W4313369080A5001023635 @default.
- W4313369080 hasAuthorship W4313369080A5003355789 @default.
- W4313369080 hasAuthorship W4313369080A5006160939 @default.
- W4313369080 hasAuthorship W4313369080A5007202760 @default.
- W4313369080 hasAuthorship W4313369080A5023956402 @default.
- W4313369080 hasAuthorship W4313369080A5026259294 @default.
- W4313369080 hasAuthorship W4313369080A5028023818 @default.
- W4313369080 hasAuthorship W4313369080A5038247492 @default.
- W4313369080 hasAuthorship W4313369080A5040647937 @default.
- W4313369080 hasAuthorship W4313369080A5041756883 @default.
- W4313369080 hasAuthorship W4313369080A5052055498 @default.
- W4313369080 hasAuthorship W4313369080A5052827209 @default.
- W4313369080 hasAuthorship W4313369080A5053694276 @default.
- W4313369080 hasAuthorship W4313369080A5080013050 @default.
- W4313369080 hasAuthorship W4313369080A5080336977 @default.
- W4313369080 hasAuthorship W4313369080A5083751926 @default.
- W4313369080 hasAuthorship W4313369080A5086913810 @default.
- W4313369080 hasConcept C170493617 @default.
- W4313369080 hasConcept C203014093 @default.
- W4313369080 hasConcept C2776914184 @default.
- W4313369080 hasConcept C2777209026 @default.
- W4313369080 hasConcept C55493867 @default.
- W4313369080 hasConcept C86803240 @default.
- W4313369080 hasConcept C95444343 @default.
- W4313369080 hasConceptScore W4313369080C170493617 @default.
- W4313369080 hasConceptScore W4313369080C203014093 @default.
- W4313369080 hasConceptScore W4313369080C2776914184 @default.
- W4313369080 hasConceptScore W4313369080C2777209026 @default.
- W4313369080 hasConceptScore W4313369080C55493867 @default.
- W4313369080 hasConceptScore W4313369080C86803240 @default.
- W4313369080 hasConceptScore W4313369080C95444343 @default.
- W4313369080 hasIssue "1_Supplement" @default.
- W4313369080 hasLocation W43133690801 @default.
- W4313369080 hasOpenAccess W4313369080 @default.
- W4313369080 hasPrimaryLocation W43133690801 @default.
- W4313369080 hasRelatedWork W1593760300 @default.
- W4313369080 hasRelatedWork W2069307976 @default.
- W4313369080 hasRelatedWork W2153328565 @default.
- W4313369080 hasRelatedWork W2154886903 @default.
- W4313369080 hasRelatedWork W2531441777 @default.
- W4313369080 hasRelatedWork W2754702609 @default.
- W4313369080 hasRelatedWork W2780415304 @default.
- W4313369080 hasRelatedWork W2891612290 @default.
- W4313369080 hasRelatedWork W4300842262 @default.
- W4313369080 hasRelatedWork W4321349246 @default.
- W4313369080 hasVolume "204" @default.
- W4313369080 isParatext "false" @default.
- W4313369080 isRetracted "false" @default.
- W4313369080 workType "article" @default.