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- W4313369097 abstract "Abstract Present work analyzes the tumoral immune response of oral molecular iodine (I2) supplementation with the conventional treatment (5-fluorouracil/epirubicin/ cyclophosphamide or taxotere/epirubicin; FEC/TE) in patients with breast cancer from Hospital General of Queretaro, Mexico. Patients diagnosed with stage II were given placebo (vegetable colored water) or I2 from diagnosis to mastectomy (7 to 40 days) while patients with stage III received placebo or I2 with neoadjuvant FEC/TE treatment (40–70 days). Transcriptomic analysis and GESA studies showed that I2 supplementation alone or in presence of FEC/TE up-regulate Th1 and Th17 differentiation pathways, activation by T-cell receptor, cytotoxicity by NK and CD8+, lymphocyte migration and formation of tertiary lymphoid structures. Deconvolution analysis indicate an increase in macrophages/dendritic cells in I2 group while in FEC/TE+I2 group exhibited increased B cells fractions. Analysis of Th1/Th2 response markers showed significant increase expression in Tbx-21 (RT-PCR) and Interferon gamma (immunohistochemistry) in the FEC/TE+I2 group. This anti-tumor immune activation correlated with the longer disease-free period (43%) and 5 years-survival (60%) observed in FEC/TE+I2 patients. Studies to analyze the effect of I2 supplementation in immunotherapies are in course." @default.
- W4313369097 created "2023-01-06" @default.
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- W4313369097 date "2020-05-01" @default.
- W4313369097 modified "2023-09-27" @default.
- W4313369097 title "Molecular iodine activates cytotoxic immune response in breast cancer tumor microenvironment" @default.
- W4313369097 doi "https://doi.org/10.4049/jimmunol.204.supp.241.8" @default.
- W4313369097 hasPublicationYear "2020" @default.
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