FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313371819> ?p ?o ?g. }

• W4313371819 endingPage "4041" @default.
• W4313371819 startingPage "4028" @default.
• W4313371819 abstract "DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson’s disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA) and noradrenaline. We report in human brain and human SH-SY5Y neuroblastoma cell lines that DJ-1 predominantly forms high molecular weight (HMW) complexes that included RNA metabolism proteins hnRNPA1 and PABP1 and the glycolysis enzyme GAPDH. In cell culture models the oxidation status of DJ-1 determined the specific complex composition. RNA sequencing indicated that oxidative changes to DJ-1 were concomitant with changes in mRNA transcripts mainly involved in catecholamine metabolism. Importantly, loss of DJ-1 function upon knock down (KD) or expression of the PD associated form L166P resulted in the absence of HMW DJ-1 complexes. In the KD model, the absence of DJ-1 complexes was accompanied by impairment in catecholamine homeostasis, with significant increases in intracellular DA and noraderenaline levels. These changes in catecholamines could be rescued by re-expression of DJ-1. This catecholamine imbalance may contribute to the particular vulnerability of dopaminergic and noradrenergic neurons to neurodegeneration in PARK7-related PD. Notably, oxidised DJ-1 was significantly decreased in idiopathic PD brain, suggesting altered complex function may also play a role in the more common sporadic form of the disease." @default.
• W4313371819 created "2023-01-06" @default.
• W4313371819 creator A5001792341 @default.
• W4313371819 creator A5001992229 @default.
• W4313371819 creator A5005926970 @default.
• W4313371819 creator A5017604542 @default.
• W4313371819 creator A5019440459 @default.
• W4313371819 creator A5020931376 @default.
• W4313371819 creator A5022319849 @default.
• W4313371819 creator A5031957131 @default.
• W4313371819 creator A5033170776 @default.
• W4313371819 creator A5051976734 @default.
• W4313371819 creator A5059770430 @default.
• W4313371819 creator A5069824544 @default.
• W4313371819 creator A5070560226 @default.
• W4313371819 creator A5074359060 @default.
• W4313371819 creator A5078093706 @default.
• W4313371819 creator A5081730832 @default.
• W4313371819 creator A5088579567 @default.
• W4313371819 creator A5088720405 @default.
• W4313371819 date "2017-07-25" @default.
• W4313371819 modified "2023-10-01" @default.
• W4313371819 title "DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis" @default.
• W4313371819 cites W1481208581 @default.
• W4313371819 cites W1539334271 @default.
• W4313371819 cites W1891167896 @default.
• W4313371819 cites W1918381051 @default.
• W4313371819 cites W1963530308 @default.
• W4313371819 cites W1967603366 @default.
• W4313371819 cites W1969984680 @default.
• W4313371819 cites W1971895154 @default.
• W4313371819 cites W1973474734 @default.
• W4313371819 cites W1976393002 @default.
• W4313371819 cites W1977990240 @default.
• W4313371819 cites W1978776771 @default.
• W4313371819 cites W1982651534 @default.
• W4313371819 cites W1986115821 @default.
• W4313371819 cites W1986263566 @default.
• W4313371819 cites W1991438753 @default.
• W4313371819 cites W2004536300 @default.
• W4313371819 cites W2005917373 @default.
• W4313371819 cites W2006421452 @default.
• W4313371819 cites W2008825369 @default.
• W4313371819 cites W2021493210 @default.
• W4313371819 cites W2021546423 @default.
• W4313371819 cites W2026875466 @default.
• W4313371819 cites W2027096397 @default.
• W4313371819 cites W2028502345 @default.
• W4313371819 cites W2033444940 @default.
• W4313371819 cites W2033988038 @default.
• W4313371819 cites W2035591404 @default.
• W4313371819 cites W2044176491 @default.
• W4313371819 cites W2053206150 @default.
• W4313371819 cites W2057558239 @default.
• W4313371819 cites W2063089997 @default.
• W4313371819 cites W2064774245 @default.
• W4313371819 cites W2073580150 @default.
• W4313371819 cites W2074397899 @default.
• W4313371819 cites W2078198674 @default.
• W4313371819 cites W2079103662 @default.
• W4313371819 cites W2080857749 @default.
• W4313371819 cites W2105631970 @default.
• W4313371819 cites W2119028277 @default.
• W4313371819 cites W2125196804 @default.
• W4313371819 cites W2127020153 @default.
• W4313371819 cites W2129755489 @default.
• W4313371819 cites W2131988270 @default.
• W4313371819 cites W2133407217 @default.
• W4313371819 cites W2134541285 @default.
• W4313371819 cites W2150634893 @default.
• W4313371819 cites W2160096490 @default.
• W4313371819 cites W2170036048 @default.
• W4313371819 cites W2171873547 @default.
• W4313371819 cites W2179438025 @default.
• W4313371819 cites W2199911847 @default.
• W4313371819 cites W2367410350 @default.
• W4313371819 cites W2529778423 @default.
• W4313371819 cites W3023135928 @default.
• W4313371819 cites W62603772 @default.
• W4313371819 doi "https://doi.org/10.1093/hmg/ddx294" @default.
• W4313371819 hasPublicationYear "2017" @default.
• W4313371819 type Work @default.
• W4313371819 citedByCount "18" @default.
• W4313371819 countsByYear W43133718192018 @default.
• W4313371819 countsByYear W43133718192019 @default.
• W4313371819 countsByYear W43133718192020 @default.
• W4313371819 countsByYear W43133718192021 @default.
• W4313371819 countsByYear W43133718192022 @default.
• W4313371819 countsByYear W43133718192023 @default.
• W4313371819 crossrefType "journal-article" @default.
• W4313371819 hasAuthorship W4313371819A5001792341 @default.
• W4313371819 hasAuthorship W4313371819A5001992229 @default.
• W4313371819 hasAuthorship W4313371819A5005926970 @default.
• W4313371819 hasAuthorship W4313371819A5017604542 @default.
• W4313371819 hasAuthorship W4313371819A5019440459 @default.
• W4313371819 hasAuthorship W4313371819A5020931376 @default.
• W4313371819 hasAuthorship W4313371819A5022319849 @default.
• W4313371819 hasAuthorship W4313371819A5031957131 @default.

• next