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- W4313372017 abstract "Abstract Study objective Recent evidence shows that subgroups of circulating B cells accumulate intravascularly in the naïve murine heart. However, the timing of their appearance and their organ specificity remain unclear. Methods and Results We performed a systematic analysis of B cells isolated from the myocardium and other organs, from mid development to early adulthood. We found that B cells are present in the developing heart already at E13.5. Myocardial associated B cells were mostly intravascular and in close association with the endothelium. Their phenotype changed rapidly. Through flow cytometry and proteogenomics analysis we found that heart associated B cells were initially almost exclusively CD11b+ and CD11b−CD21−CD23− but became mostly CD11b−CD21+CD23+ cells at 5 weeks of age. Importantly, comparative analysis of B cells isolated from perfused hearts, livers, lungs, spleen and peripheral blood at different time points showed that the B cells isolated from the heart were in equilibrium with both splenic/circulating B cells and B cells isolated from other organs, but they had specific features. This finding was confirmed through simultaneous 10X single cells sequencing of hashtag labelled B cells. Conclusions Taken together these observations highlight that myocardial associated B cells are part of a tightly regulated population of circulating B lymphocytes that exists in multiple organs and is in dynamic equilibrium with the spleen and peripheral blood B cells. Further work will be needed to identify the molecular mechanisms that lead to the accumulation of specific subsets of circulating B cells in peripheral organs and to investigate their functional significance." @default.
- W4313372017 created "2023-01-06" @default.
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- W4313372017 date "2020-05-01" @default.
- W4313372017 modified "2023-09-27" @default.
- W4313372017 title "Myocardial associated B cells are a dynamic subgroup of circulating B cells, in equilibrium with splenic and circulating B cells, but with organ specific features" @default.
- W4313372017 doi "https://doi.org/10.4049/jimmunol.204.supp.153.14" @default.
- W4313372017 hasPublicationYear "2020" @default.
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