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- W4313372040 abstract "Abstract Enteropathogenic E. coli (EPEC) is one of the leading causes of diarrheal disease among children. Citrobacter rodentium (C.r) is a mouse model for EPEC and neutrophils have been found to be required for effective host protection against C.r. Yet details of the cellular sources that control neutrophil recruitment during C.r infection are poorly understood. Here we have found that C.r infection promotes neutrophil recruitment that is limited to distal colon where C.r colonizes. C.r infection induces the neutrophil-recruiting chemokines CXCL1, CXCL2 and CXCL5 in distal colon. Early in infection (D4) intestinal epithelial cells serve as the dominant source of CXCL1/2/5. However, later in infection (D8) neutrophils also provide CXCL1 and CXCL2, but fail to produce CXCL5, production of which is sustained in superficial epithelial cells. These findings support a model in which production of neutrophil-attracting chemokines is initiated in the infected epithelium and is amplified in a feedforward manner by incoming neutrophils. However, the unique production of CXCL5 by epithelial cells may be essential to recruit neutrophils to the mucosal surface, which C.r colonizes during infection." @default.
- W4313372040 created "2023-01-06" @default.
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- W4313372040 date "2020-05-01" @default.
- W4313372040 modified "2023-09-27" @default.
- W4313372040 title "Temporal changes in cellular sources of CXC chemokines control neutrophil recruitment during Citrobacter rodentium infection" @default.
- W4313372040 doi "https://doi.org/10.4049/jimmunol.204.supp.158.22" @default.
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