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- W4313372481 abstract "Summary The mechanism of immunity was studied in the case of the viruses of equine encephalomyelitis and rabies. The antibody contents of the immune sera were determined by injecting a mixture of a constant dose of virus and varying doses of immune serum into the intraventricular space of guinea-pigs. These experiments were designated as direct tests and the minimal neutralizing doses of immune serum as Ad. The capacity of the immune sera to confer passive immunity was measured by injecting the same dose of virus into the intraventricular space and varying doses of immune serum intravenously. These experiments were designated as indirect tests and the minimal neutralizing doses of immune serum as Ai. The ratio Ai/Ad was found to be at least 1280 for the virus of rabies and approximately 10 for the virus of equine encephalomyelitis. In the case of the virus of equine encephalomyelitis Ad is the same for non-incubated mixtures and mixtures incubated for 20 hours at room-temperature. In the case of the virus of rabies Ad is considerably lower for incubated mixtures. The virus of equine encephalomyelitis and its antibody do not combine in vitro once the immune serum is diluted to more than 1:4. On the contrary, the virus of rabies and its antibody combine in vitro even if the immune serum is highly diluted." @default.
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- W4313372481 date "1944-04-01" @default.
- W4313372481 modified "2023-09-27" @default.
- W4313372481 title "Studies on Virus Immunity" @default.
- W4313372481 doi "https://doi.org/10.4049/jimmunol.48.4.247" @default.
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