FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313372661> ?p ?o ?g. }

• W4313372661 endingPage "124" @default.
• W4313372661 startingPage "115" @default.
• W4313372661 abstract "With modern treatment most children with acute lymphoblastic leukemia (ALL) survive without relapse. However, for children who relapse the prognosis is still poor, especially in children with T-cell phenotype (T-ALL) and remains the major cause of death. The exact mechanism of relapse is currently not known. While contribution of RNA processing alteration has been linked to other hematological malignancies, its contribution in pediatric T-ALL may provide new insights. Almost all human genes express more than one alternative splice isoform. Thus, gene modulation producing a diverse repertoire of the transcriptome and proteome have become a significant molecular marker of cancer and a potential therapeutic vulnerability. To study this, we performed RNA-sequencing analysis on patient-derived samples followed by splice isoform-specific PCR. We uncovered a distinct RNA splice isoform expression pattern characteristic for relapse samples compared to the leukemia samples from the time of diagnosis. We also identified deregulated splicing and apoptosis pathways specific for relapse T-ALL. Moreover, patients with T-ALL displayed pro-survival splice isoform switching favoring pro-survival isoforms compared to normal healthy stem cells. Cumulatively, pro-survival isoform switching and DFFB isoform regulation of SOX2 and MYCN may play a role in T-ALL proliferation and survival, thus serving as a potential therapeutic option." @default.
• W4313372661 created "2023-01-06" @default.
• W4313372661 creator A5015567980 @default.
• W4313372661 creator A5030978536 @default.
• W4313372661 creator A5032058170 @default.
• W4313372661 creator A5035001890 @default.
• W4313372661 creator A5041007879 @default.
• W4313372661 creator A5045770018 @default.
• W4313372661 creator A5047814015 @default.
• W4313372661 creator A5071991831 @default.
• W4313372661 creator A5080598612 @default.
• W4313372661 date "2022-12-30" @default.
• W4313372661 modified "2023-10-09" @default.
• W4313372661 title "Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T‐cell acute lymphoblastic leukemia" @default.
• W4313372661 cites W1970108031 @default.
• W4313372661 cites W1974999667 @default.
• W4313372661 cites W1975482936 @default.
• W4313372661 cites W1990792484 @default.
• W4313372661 cites W2002238399 @default.
• W4313372661 cites W2008757142 @default.
• W4313372661 cites W2029664411 @default.
• W4313372661 cites W2054103222 @default.
• W4313372661 cites W2114031931 @default.
• W4313372661 cites W2120132028 @default.
• W4313372661 cites W2152061559 @default.
• W4313372661 cites W2157912474 @default.
• W4313372661 cites W2182727161 @default.
• W4313372661 cites W2258573009 @default.
• W4313372661 cites W2413340136 @default.
• W4313372661 cites W2516282811 @default.
• W4313372661 cites W2553938351 @default.
• W4313372661 cites W2599212387 @default.
• W4313372661 cites W2610081389 @default.
• W4313372661 cites W2755386540 @default.
• W4313372661 cites W2789924919 @default.
• W4313372661 cites W2793462451 @default.
• W4313372661 cites W2795877840 @default.
• W4313372661 cites W2888644397 @default.
• W4313372661 cites W2898888984 @default.
• W4313372661 cites W3005260029 @default.
• W4313372661 cites W3033939075 @default.
• W4313372661 cites W3136185425 @default.
• W4313372661 cites W3159949404 @default.
• W4313372661 cites W4220788861 @default.
• W4313372661 cites W4280550963 @default.
• W4313372661 doi "https://doi.org/10.1002/jha2.634" @default.
• W4313372661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36819185" @default.
• W4313372661 hasPublicationYear "2022" @default.
• W4313372661 type Work @default.
• W4313372661 citedByCount "1" @default.
• W4313372661 countsByYear W43133726612023 @default.
• W4313372661 crossrefType "journal-article" @default.
• W4313372661 hasAuthorship W4313372661A5015567980 @default.
• W4313372661 hasAuthorship W4313372661A5030978536 @default.
• W4313372661 hasAuthorship W4313372661A5032058170 @default.
• W4313372661 hasAuthorship W4313372661A5035001890 @default.
• W4313372661 hasAuthorship W4313372661A5041007879 @default.
• W4313372661 hasAuthorship W4313372661A5045770018 @default.
• W4313372661 hasAuthorship W4313372661A5047814015 @default.
• W4313372661 hasAuthorship W4313372661A5071991831 @default.
• W4313372661 hasAuthorship W4313372661A5080598612 @default.
• W4313372661 hasBestOaLocation W43133726611 @default.
• W4313372661 hasConcept C104317684 @default.
• W4313372661 hasConcept C121608353 @default.
• W4313372661 hasConcept C127716648 @default.
• W4313372661 hasConcept C150194340 @default.
• W4313372661 hasConcept C162317418 @default.
• W4313372661 hasConcept C194583182 @default.
• W4313372661 hasConcept C203014093 @default.
• W4313372661 hasConcept C2778461978 @default.
• W4313372661 hasConcept C2780989783 @default.
• W4313372661 hasConcept C502942594 @default.
• W4313372661 hasConcept C53345823 @default.
• W4313372661 hasConcept C54355233 @default.
• W4313372661 hasConcept C54458228 @default.
• W4313372661 hasConcept C67705224 @default.
• W4313372661 hasConcept C86803240 @default.
• W4313372661 hasConceptScore W4313372661C104317684 @default.
• W4313372661 hasConceptScore W4313372661C121608353 @default.
• W4313372661 hasConceptScore W4313372661C127716648 @default.
• W4313372661 hasConceptScore W4313372661C150194340 @default.
• W4313372661 hasConceptScore W4313372661C162317418 @default.
• W4313372661 hasConceptScore W4313372661C194583182 @default.
• W4313372661 hasConceptScore W4313372661C203014093 @default.
• W4313372661 hasConceptScore W4313372661C2778461978 @default.
• W4313372661 hasConceptScore W4313372661C2780989783 @default.
• W4313372661 hasConceptScore W4313372661C502942594 @default.
• W4313372661 hasConceptScore W4313372661C53345823 @default.
• W4313372661 hasConceptScore W4313372661C54355233 @default.
• W4313372661 hasConceptScore W4313372661C54458228 @default.
• W4313372661 hasConceptScore W4313372661C67705224 @default.
• W4313372661 hasConceptScore W4313372661C86803240 @default.
• W4313372661 hasIssue "1" @default.
• W4313372661 hasLocation W43133726611 @default.
• W4313372661 hasLocation W43133726612 @default.
• W4313372661 hasLocation W43133726613 @default.
• W4313372661 hasOpenAccess W4313372661 @default.
• W4313372661 hasPrimaryLocation W43133726611 @default.

• next