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- W4313372780 abstract "Abstract The serum of the mouse differs from that of most animals in that it is without complementary activity. Its serum fails to hemolyze sensitized sheep-cells. Ritz in 1911 (1) observed that mouse-serum contains one component of complement called the midpiece but that the endpiece is missing. This phenomenon is analogous to that given by the fresh serum from a strain of complement-deficient guinea-pigs first reported by Moore (2). A thorough study of this serum by Coca (3), Ecker (4) and Hyde (5, 6) has shown that it is activated in a hemolytic system by very small amounts of heated serum from man or the normal guinea-pig. Thus, the midpiece and endpiece of complement are normally present in this serum but the third complement-component, the heat-resistant or yeast-absorbed component, is missing. The separation by various methods of guinea-pig complement into several components has been described by Leifmann (7, 8), Browning and Mackie (9) and Whitehead, Gordon, and Wormall (10, 11)." @default.
- W4313372780 created "2023-01-06" @default.
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- W4313372780 date "1943-05-01" @default.
- W4313372780 modified "2023-09-30" @default.
- W4313372780 title "The Complementary Activity of Mouse-Serum" @default.
- W4313372780 doi "https://doi.org/10.4049/jimmunol.46.5.319" @default.
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