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- W4313373322 abstract "Abstract We recently reported that treatment of SCID-X1 infants (X-linked severe combined immunodeficiency) with autologous bone marrow expressing the corrected IL2RG resulted in reconstitution of T, B, and NK cells (Mamcarz et al., NEJM. 2019). Longitudinal observation of these patients undergoing immune reconstitution affords the unique ability to study human T cell development in real time. Accordingly, we observed that during the first few weeks of reconstitution, T cells egressing early into the peripheral blood were primarily demarcated by CD45RO+ expression, a memory phenotype. After establishing memory-like cells, CCR7+CD45RO− naive T cells appeared, and both populations continued to increase in absolute counts over time. Phenotypic analysis of CD45RO+ cells demonstrated an enrichment of NKG2A+ memory-like phenotype (MP) T cells. Moreover, epigenetic analysis by DNA methylation profiling of CD45RO+ cells exhibited a hybrid state of naïve and effector programs among the memory population. Culture of isolated MP T cells in IL-12/IL-18 from SCID-X1 patients resulted in expression of IFNg in an antigen-independent manner. Collectively, these data suggest that MP T cells develop early in humans and are endowed with the capacity to rapidly elicit effector cytokines in an antigen-independent manner." @default.
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- W4313373322 date "2020-05-01" @default.
- W4313373322 modified "2023-10-14" @default.
- W4313373322 title "<i>De novo</i> T cell development in humans favors the early formation of memory phenotype cells: insights from SCID-X1 patients treated with gene therapy" @default.
- W4313373322 doi "https://doi.org/10.4049/jimmunol.204.supp.61.10" @default.
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