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• W4313373337 endingPage "80.18" @default.
• W4313373337 startingPage "80.18" @default.
• W4313373337 abstract "Abstract Exhausted immune responses to chronic diseases represent a major challenge to global health. We studied CD4+ T cells in a mouse model where presentation of their antigen can be regulated. When the cells are driven through the effector phase, but are then exposed to different levels of persistent antigen, they lose their Th1 functions, upregulate exhaustion and anergy markers, modulate their MAP kinase, mTORC1 and Ca2+/calcineurin signaling pathways with dose and time, lose their capacity to transmit help to B cells and undergo, at the highest dose, apoptosis. Transcriptomic analyses show the dynamic adjustment of gene expression and the accumulation of TCR signals over a period of weeks. The cells also adapt to antigen removal and recover their functionality while losing exhaustion and anergy markers. Our data suggest an adjustable response of CD4+ T cells to different levels of persisting antigen and contribute to a better understanding of chronic disease." @default.
• W4313373337 created "2023-01-06" @default.
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• W4313373337 date "2020-05-01" @default.
• W4313373337 modified "2023-09-27" @default.
• W4313373337 title "Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells" @default.
• W4313373337 doi "https://doi.org/10.4049/jimmunol.204.supp.80.18" @default.
• W4313373337 hasPublicationYear "2020" @default.
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