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- W4313373357 abstract "Abstract Histone H3K27 demethylase, JMJD3 plays a critical role in gene expression and T-cell differentiation. However, the role and mechanisms of JMJD3 in T cell trafficking remain poorly understood. Here we show that JMJD3 deficiency in CD4+ T cells resulted in T cell trafficking deficiency autoimmune disease models and adoptive immunotherapy models. We identified PDLIM4 and S1P1 as significantly down-regulated target genes in JMJD3-deficient CD4+ T cells by gene profiling and ChIP-seq analyses. The further study showed that PDLIM4 regulate actin cytoskeleton, thus serving as a key regulator of T cell trafficking. These results demonstrate that manipulating JMJD3 expression can benefit autoimmune disease treatment and generate better T cell grafts for adoptive immunotherapy." @default.
- W4313373357 created "2023-01-06" @default.
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- W4313373357 date "2020-05-01" @default.
- W4313373357 modified "2023-10-12" @default.
- W4313373357 title "JMJD3-deficient impair CD4 T cell trafficking in autoimmune disease models and adoptive immunotherapy models by targeting cytoskeleton genes" @default.
- W4313373357 doi "https://doi.org/10.4049/jimmunol.204.supp.238.21" @default.
- W4313373357 hasPublicationYear "2020" @default.
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