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- W4313373367 abstract "Abstract Gulf War Illness (GWI) encompasses multisymptom disorders characterized by chronic fatigue exhibiting neuromuscular involvement, affecting a considerable number of veterans who served the Persian Gulf War between 1990–91. Every war brings home soldiers with some acute/chronic disorders, but this multisymptom illness categorized as GWI is being investigated for 28 years because the treatments have been only palliative in spite of the considerable effort to treat the veterans to wellness. There are still unmet needs in understanding the pathobiology of GWI. Several studies conducted so far attribute the cause to chemical and biological exposures. From in-vivo studies, it can be deduced that the combined repetitive exposures to various neurotoxic chemicals insistently altered cellular receptors. Further, prophylactic treatments such as pyridostigmine bromide, anti-nerve gas pills, glucocorticoids, corticosterone, and vaccines not only primed the immune system but also paradoxically triggered the CNS-glymphatic system to mount a neuroinflammatory response in some individuals. This study focused on relative estimates of complement components and the convertases in the plasma, considering the immune system is the primary defense consisting of high polymorphism combined with a wide range of soluble factors. Complement components from C1 to C9 show high variability in 25 veterans with GWI compared to 20 healthy controls and other referenced neuromuscular disorders. Although C1 is the first responder of the classical pathway, consistently and significantly C1q, C5b, C7, factor D, and properdin were upregulated with the highest variability in veterans with GWI (p<0.001), indicating distinct variance in the immune complex." @default.
- W4313373367 created "2023-01-06" @default.
- W4313373367 creator A5002996849 @default.
- W4313373367 date "2020-05-01" @default.
- W4313373367 modified "2023-09-27" @default.
- W4313373367 title "Immune response reflecting the involvement of Complement components in Gulf War illness" @default.
- W4313373367 doi "https://doi.org/10.4049/jimmunol.204.supp.64.16" @default.
- W4313373367 hasPublicationYear "2020" @default.
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