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- W4313373384 abstract "Abstract Important immune regulatory mechanisms mediated by CD4+ and CD8+ T-cells keep destructive CD4+ T-cell responses in check. CD4+ T-helper 17 (Th17) cells, characterized by IL-17 production, play critical roles in the body’s response to infections and cancer and in the pathogenesis of autoimmune diseases such as multiple sclerosis, psoriasis, arthritis, IBD, among others. Here, we demonstrate that human CD4+ T-cells exposed to a Th17-differentiating milieu are highly resistant to immune suppression by CD8+ T-cells, compared to control Th0 cells. This resistance is mediated, in part, through the action of IL-17A, IL-17F and IL-17AF heterodimer through their receptors (IL-17RA and IL-17RC) on CD4+ T-cells themselves, but not through their action on CD8+ T-cells or APC. We further show that IL-17 can directly act on non-Th17 effector CD4+ T-cells to induce suppressive resistance through the induction of IL-1b and IL-6/STAT3 pathways, indicating a novel feedback loop. These studies reveal a novel function for IL-17 cytokines in a CD4-intrinsic mechanism of immune resistance. The pathways induced in this process may serve as a critical target for intensive investigation and therapeutic intervention." @default.
- W4313373384 created "2023-01-06" @default.
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- W4313373384 date "2020-05-01" @default.
- W4313373384 modified "2023-09-27" @default.
- W4313373384 title "Novel role for T-helper 17 signature cytokine, IL-17, in inducing CD4 effector resistance to immune suppression" @default.
- W4313373384 doi "https://doi.org/10.4049/jimmunol.204.supp.228.3" @default.
- W4313373384 hasPublicationYear "2020" @default.
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