Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373409> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313373409 endingPage "235.2" @default.
- W4313373409 startingPage "235.2" @default.
- W4313373409 abstract "Abstract Infants exhibit increased susceptibility to viral and bacterial pathogens with pulmonary infections representing one of the top causes of infant mortality worldwide. Optimal protection from pathogens is mediated by coordinated functions of different T cell subsets, with tissue resident populations maintaining site-specific immunity in the respiratory tract. Currently, little is known of how tissue localized T cells populate and mediate mucosal immune responses in early life in humans. Here we analyzed T cell populations in the lungs obtained from infant and pediatric organ donors aged 8 days postnatal (PN) to 8 years by imaging and flow cytometry. In the earliest stage of life at 8 days PN, few αβ T cells were present in the lung, while innate-type γδ T cells were present around the airways. During the first two years of life, αβ T cells exhibiting memory phenotypes preferentially accumulated around the central airways and expressed canonical markers of tissue residency (CD69 and CD103), consistent with flow cytometry data. By contrast, the total number of γδ T cells in the lung did not change significantly with age for up to 8 years of life; for example, the ratio of αβ:γδ T cells in neonatal donors was 1.5:1, which increased to 16:1 in lungs of a 3 year old donor. Consistent with the imaging data, the frequency of γδ T cells by flow cytometry was significantly reduced after the early neonatal period. These results show that γδ T cells populate the lung during the early neonatal period and are maintained in relatively constant numbers over childhood, while tissue resident αβ T cells accumulate over first 2 years of life and predominate thereafter. Our results demonstrate the dynamic nature of lung-localized T cell immune responses in a mucosal site." @default.
- W4313373409 created "2023-01-06" @default.
- W4313373409 creator A5016121976 @default.
- W4313373409 creator A5017086985 @default.
- W4313373409 creator A5056997693 @default.
- W4313373409 creator A5065092305 @default.
- W4313373409 creator A5069975499 @default.
- W4313373409 creator A5074965872 @default.
- W4313373409 creator A5080612374 @default.
- W4313373409 creator A5087661900 @default.
- W4313373409 date "2020-05-01" @default.
- W4313373409 modified "2023-10-02" @default.
- W4313373409 title "Early dynamic accumulation of tissue resident memory T cells in the human lung during infancy" @default.
- W4313373409 doi "https://doi.org/10.4049/jimmunol.204.supp.235.2" @default.
- W4313373409 hasPublicationYear "2020" @default.
- W4313373409 type Work @default.
- W4313373409 citedByCount "0" @default.
- W4313373409 crossrefType "journal-article" @default.
- W4313373409 hasAuthorship W4313373409A5016121976 @default.
- W4313373409 hasAuthorship W4313373409A5017086985 @default.
- W4313373409 hasAuthorship W4313373409A5056997693 @default.
- W4313373409 hasAuthorship W4313373409A5065092305 @default.
- W4313373409 hasAuthorship W4313373409A5069975499 @default.
- W4313373409 hasAuthorship W4313373409A5074965872 @default.
- W4313373409 hasAuthorship W4313373409A5080612374 @default.
- W4313373409 hasAuthorship W4313373409A5087661900 @default.
- W4313373409 hasConcept C104317684 @default.
- W4313373409 hasConcept C126322002 @default.
- W4313373409 hasConcept C127716648 @default.
- W4313373409 hasConcept C142724271 @default.
- W4313373409 hasConcept C203014093 @default.
- W4313373409 hasConcept C2776090121 @default.
- W4313373409 hasConcept C2777714996 @default.
- W4313373409 hasConcept C2779341262 @default.
- W4313373409 hasConcept C553184892 @default.
- W4313373409 hasConcept C55493867 @default.
- W4313373409 hasConcept C71924100 @default.
- W4313373409 hasConcept C86803240 @default.
- W4313373409 hasConcept C8891405 @default.
- W4313373409 hasConceptScore W4313373409C104317684 @default.
- W4313373409 hasConceptScore W4313373409C126322002 @default.
- W4313373409 hasConceptScore W4313373409C127716648 @default.
- W4313373409 hasConceptScore W4313373409C142724271 @default.
- W4313373409 hasConceptScore W4313373409C203014093 @default.
- W4313373409 hasConceptScore W4313373409C2776090121 @default.
- W4313373409 hasConceptScore W4313373409C2777714996 @default.
- W4313373409 hasConceptScore W4313373409C2779341262 @default.
- W4313373409 hasConceptScore W4313373409C553184892 @default.
- W4313373409 hasConceptScore W4313373409C55493867 @default.
- W4313373409 hasConceptScore W4313373409C71924100 @default.
- W4313373409 hasConceptScore W4313373409C86803240 @default.
- W4313373409 hasConceptScore W4313373409C8891405 @default.
- W4313373409 hasIssue "1_Supplement" @default.
- W4313373409 hasLocation W43133734091 @default.
- W4313373409 hasOpenAccess W4313373409 @default.
- W4313373409 hasPrimaryLocation W43133734091 @default.
- W4313373409 hasRelatedWork W2035492084 @default.
- W4313373409 hasRelatedWork W2057948995 @default.
- W4313373409 hasRelatedWork W2153797564 @default.
- W4313373409 hasRelatedWork W2223869382 @default.
- W4313373409 hasRelatedWork W2947413141 @default.
- W4313373409 hasRelatedWork W2993057445 @default.
- W4313373409 hasRelatedWork W3017822181 @default.
- W4313373409 hasRelatedWork W3032210197 @default.
- W4313373409 hasRelatedWork W4281925851 @default.
- W4313373409 hasRelatedWork W573847062 @default.
- W4313373409 hasVolume "204" @default.
- W4313373409 isParatext "false" @default.
- W4313373409 isRetracted "false" @default.
- W4313373409 workType "article" @default.