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- W4313373419 startingPage "71.14" @default.
- W4313373419 abstract "Abstract Belonging to innate immunity, natural killer (NK) cells constitute of circulating lymphocytes which provide a body’s first line of defense against infection and cancer. In the spleen,, NK cells are likely to interact with B cells, but the functional consequence of this interaction remains uncertain. To address this question, we co-cultured primary NK cells with freshly isolated B cells from the spleen and investigated the influence of B cells on NK cells. Here we show that co-presence of B cells in cultures facilitated proliferation of NK cells, as measured CFSE dilution assays. CFSE results showed that proliferation of NK cells by B cells need direct and in direct stimulation. This correlated with microarray data showing that expression of genes involved in the regulation of cell proliferation was significantly increased in NK cells in NK-B co-cultures. NK cells cultured with B cells exhibited higher expression of CD69, B220, CD25 activation markers, suggesting that B cells drastically facilitated NK cell activation. Lack of B cells in mice weakened anti-tumor effect as well as anti-pathogen response, suggesting that NK cells exhibited higher anti-tumor activity in the presence of B cells. The synergistic effect of B cells on NK cell functions also occurred in humans. Given the fact that NK cells can exert a regulatory role in cancer or infection, co-presence of B cells can potentiate the role of NK cells by promoting their proliferation and cytotoxicity." @default.
- W4313373419 created "2023-01-06" @default.
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- W4313373419 date "2020-05-01" @default.
- W4313373419 modified "2023-09-25" @default.
- W4313373419 title "B cell-mediated activation and proliferation of NK cells : crossroads of adaptive and innate immunity" @default.
- W4313373419 doi "https://doi.org/10.4049/jimmunol.204.supp.71.14" @default.
- W4313373419 hasPublicationYear "2020" @default.
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