Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373424> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4313373424 endingPage "165.47" @default.
- W4313373424 startingPage "165.47" @default.
- W4313373424 abstract "Abstract Despite the high tumor mutational burden (TMB), immune checkpoint blockade (ICB) still fails in some microsatellite instability-high (MSI-H) tumors, suggesting the underlying T cell dysfunction. Immune profiling of PBMC from chemotherapy-resistant MSI-H uterine cancer patients treated with nivolumab identified the proliferative T cell response 2–4 weeks post PD-1 blockade. However, this “immunological response” to ICB was observed regardless of clinical response, suggesting the additional determinants of clinical outcome beyond the proliferative response or high TMB. To test the hypothesis that the gap between immunological and clinical response to ICB was related to T celI-intrinsic response to genotoxic and/or proliferative stress, a novel high dimensional cytometry platform was developed. The platform enables simultaneous analysis of T cell differentiation state and interrogation of multiple DNA damage and repair response (DDR) pathways at single cell resolution. This DDR-Immune platform revealed consistent T cell subset specific patterns of DDR, as well as specific DDR pathways induced by different types of DNA damage. Application of the DDR-Immune platform to this cohort revealed that, in clinical responders, Ki67+ CD8 T cells had rapid increase of pATM, presumably in response to proliferative stress induced by PD-1 blockade. This DDR was not clearly observed in clinical non-responders. In addition, Tregs from clinical non-responders had elevated DDRs compared to responders, suggesting their greater resistance to genotoxic/proliferative stress. Collectively, the new platform reveals previously unrecognized roles for T cell-intrinsic DDR as a novel determinant of immune responsiveness and clinical outcome." @default.
- W4313373424 created "2023-01-06" @default.
- W4313373424 creator A5004706727 @default.
- W4313373424 creator A5024907344 @default.
- W4313373424 creator A5026953370 @default.
- W4313373424 creator A5028046240 @default.
- W4313373424 creator A5037138699 @default.
- W4313373424 creator A5037836890 @default.
- W4313373424 creator A5057824723 @default.
- W4313373424 creator A5081974951 @default.
- W4313373424 creator A5085615766 @default.
- W4313373424 creator A5088868602 @default.
- W4313373424 date "2020-05-01" @default.
- W4313373424 modified "2023-09-28" @default.
- W4313373424 title "T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade" @default.
- W4313373424 doi "https://doi.org/10.4049/jimmunol.204.supp.165.47" @default.
- W4313373424 hasPublicationYear "2020" @default.
- W4313373424 type Work @default.
- W4313373424 citedByCount "0" @default.
- W4313373424 crossrefType "journal-article" @default.
- W4313373424 hasAuthorship W4313373424A5004706727 @default.
- W4313373424 hasAuthorship W4313373424A5024907344 @default.
- W4313373424 hasAuthorship W4313373424A5026953370 @default.
- W4313373424 hasAuthorship W4313373424A5028046240 @default.
- W4313373424 hasAuthorship W4313373424A5037138699 @default.
- W4313373424 hasAuthorship W4313373424A5037836890 @default.
- W4313373424 hasAuthorship W4313373424A5057824723 @default.
- W4313373424 hasAuthorship W4313373424A5081974951 @default.
- W4313373424 hasAuthorship W4313373424A5085615766 @default.
- W4313373424 hasAuthorship W4313373424A5088868602 @default.
- W4313373424 hasConcept C104317684 @default.
- W4313373424 hasConcept C134935766 @default.
- W4313373424 hasConcept C143425029 @default.
- W4313373424 hasConcept C167672396 @default.
- W4313373424 hasConcept C170493617 @default.
- W4313373424 hasConcept C180754005 @default.
- W4313373424 hasConcept C203014093 @default.
- W4313373424 hasConcept C2776090121 @default.
- W4313373424 hasConcept C2777701055 @default.
- W4313373424 hasConcept C2778468042 @default.
- W4313373424 hasConcept C2779767149 @default.
- W4313373424 hasConcept C2780030458 @default.
- W4313373424 hasConcept C2780851360 @default.
- W4313373424 hasConcept C502942594 @default.
- W4313373424 hasConcept C54355233 @default.
- W4313373424 hasConcept C552990157 @default.
- W4313373424 hasConcept C61320498 @default.
- W4313373424 hasConcept C71924100 @default.
- W4313373424 hasConcept C86803240 @default.
- W4313373424 hasConcept C8891405 @default.
- W4313373424 hasConceptScore W4313373424C104317684 @default.
- W4313373424 hasConceptScore W4313373424C134935766 @default.
- W4313373424 hasConceptScore W4313373424C143425029 @default.
- W4313373424 hasConceptScore W4313373424C167672396 @default.
- W4313373424 hasConceptScore W4313373424C170493617 @default.
- W4313373424 hasConceptScore W4313373424C180754005 @default.
- W4313373424 hasConceptScore W4313373424C203014093 @default.
- W4313373424 hasConceptScore W4313373424C2776090121 @default.
- W4313373424 hasConceptScore W4313373424C2777701055 @default.
- W4313373424 hasConceptScore W4313373424C2778468042 @default.
- W4313373424 hasConceptScore W4313373424C2779767149 @default.
- W4313373424 hasConceptScore W4313373424C2780030458 @default.
- W4313373424 hasConceptScore W4313373424C2780851360 @default.
- W4313373424 hasConceptScore W4313373424C502942594 @default.
- W4313373424 hasConceptScore W4313373424C54355233 @default.
- W4313373424 hasConceptScore W4313373424C552990157 @default.
- W4313373424 hasConceptScore W4313373424C61320498 @default.
- W4313373424 hasConceptScore W4313373424C71924100 @default.
- W4313373424 hasConceptScore W4313373424C86803240 @default.
- W4313373424 hasConceptScore W4313373424C8891405 @default.
- W4313373424 hasIssue "1_Supplement" @default.
- W4313373424 hasLocation W43133734241 @default.
- W4313373424 hasOpenAccess W4313373424 @default.
- W4313373424 hasPrimaryLocation W43133734241 @default.
- W4313373424 hasRelatedWork W2437736820 @default.
- W4313373424 hasRelatedWork W2596919342 @default.
- W4313373424 hasRelatedWork W2795873972 @default.
- W4313373424 hasRelatedWork W2820886885 @default.
- W4313373424 hasRelatedWork W2887121575 @default.
- W4313373424 hasRelatedWork W3096809569 @default.
- W4313373424 hasRelatedWork W3177607563 @default.
- W4313373424 hasRelatedWork W4206362823 @default.
- W4313373424 hasRelatedWork W4294343845 @default.
- W4313373424 hasRelatedWork W4313373424 @default.
- W4313373424 hasVolume "204" @default.
- W4313373424 isParatext "false" @default.
- W4313373424 isRetracted "false" @default.
- W4313373424 workType "article" @default.