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- W4313373454 startingPage "71.3" @default.
- W4313373454 abstract "Abstract Germinal centre (GC) B cells are routinely identified through distinct changes on their surface carbohydrates, called glycans; yet, whether these modifications play an essential role in GC reaction remain unknown. One striking change relates to the monosaccharide sialic acid. In mice, this change is mediated through downregulation of an enzyme called Cmah. As a consequence, GC B cells lose the preferred ligand for CD22, a member of the sialic acid-binding immunoglobulin-type lectins (Siglecs) and a co-inhibitory receptor of the B cell antigen receptor. Since CD22 regulates B cell function, we hypothesize that this specific glycan remodelling on B cells control the GC reaction by modulating the activity of CD22. To test our hypothesis, we developed a mouse model that constitutively expresses Cmah in B cells. Following immunization, we find that sustained expression of Cmah in B cells results in impaired generation of antigen-specific GC B cells. More significantly, this observed defect is dependent on CD22, highlighting that coordinated loss of preferred ligands for CD22 on B cells plays a critical function in the GC. Furthermore, antibody affinity maturation is significantly impaired in immunized mice harbouring B cells which lack either CD22 or its cis glycan ligands, further supporting the role of CD22 and its glycan ligands in the GC. Ongoing efforts are focused on defining the GC-specific nature of these observations and examining potential mechanism related to BCR signalling, GC B cell survival and exit to plasma cells, and B-T cell interactions." @default.
- W4313373454 created "2023-01-06" @default.
- W4313373454 creator A5054360706 @default.
- W4313373454 creator A5057539319 @default.
- W4313373454 creator A5087354201 @default.
- W4313373454 date "2020-05-01" @default.
- W4313373454 modified "2023-09-27" @default.
- W4313373454 title "Glycan Remodelling Controls Germinal Centre B cell Responses" @default.
- W4313373454 doi "https://doi.org/10.4049/jimmunol.204.supp.71.3" @default.
- W4313373454 hasPublicationYear "2020" @default.
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