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- W4313373459 abstract "Abstract Over thirty percent of individuals infected with human immunodeficiency virus type 1 (HIV) worldwide suffer from HIV-associated neurocognitive disorder (HAND). GFAP-gp120 transgenic (Tg) mice serve as an excellent model system for HAND because they manifest the same neuropathological attributes observed in the brains of AIDS patients. In this study, we sought to identify novel genes associated with the GFAP-gp120 neurodegenerative mouse model. Von Frey filament and hot plate tests on 8 month old GFAP-gp120 mice resulted in a significant increase in mechanical and thermal nociception in Tg versus wild-type mice. Neuropathology was confirmed via immunohistochemistry of MAP2, Synaptophysin, Iba-1, and GFAP. The MAP2 and Synaptophysin allowed us to visualize dendritic density and synaptic loss. Infiltration of macrophages was observed with anti-Iba-1 and astrocytosis with anti-GFAP Abs. Additionally, single cell RNA sequencing (scRNASeq) of encephalitogenic mononuclear cells illustrated 10 distinct clusters of cells. These clusters included: astrocytes, neurons, oligodendrocytes, endothelial cells, microglia, and macrophages. Differential expression analysis showed decreased expression of GM42031 in Tg macrophages and microglia. This locus is currently unclassified and thought to be either a long non coding RNA (lncRNA) or a gene for a NYNRIN-like protein. Until now, this particular RNA has not been associated with the GFAP-gp120 disease model. However, there has been some association of GM42031 with macrophage regulation in Parkinson’s disease and colitis models. Together our study provides novel insights into the immunopathology of HAND that may form the basis for development of effective therapeutics." @default.
- W4313373459 created "2023-01-06" @default.
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- W4313373459 date "2020-05-01" @default.
- W4313373459 modified "2023-09-27" @default.
- W4313373459 title "Single cell profiling illustrates down-regulation of GM42031 in macrophages and microglia as a potential mechanism of neuroinflammation in transgenic GFAP-gp120 mice" @default.
- W4313373459 doi "https://doi.org/10.4049/jimmunol.204.supp.225.12" @default.
- W4313373459 hasPublicationYear "2020" @default.
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