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- W4313373472 abstract "Abstract The gut, lung, and skin are physical and immunological barriers that serve as the first line of defense against pathogens and foreign substances. Due to sampling limitations, previous studies have been limited to studying human barrier sites in isolation and often in the context of specific diseases. Our donor tissue resource established in collaboration with LiveOnNY offers a unique opportunity to examine human barrier T cell immunity as a network and elucidate how barrier sites are connected to each other and to lymphoid sites (lymph nodes, bone marrow, spleen). Here, using cytometry by time-of-flight (CyTOF) and T cell receptor (TCR) CDR3b sequencing, we investigate the unique defining characteristics and connectivity of T cells in barrier tissue – gut, lung, and skin – to lymphoid sites and blood. Through high-dimensional marker analysis by CyTOF, our results show that T cell subset composition and phenotype across 8 different sites comprise 33 clusters that are highly conserved between donors of different ages (22–70 yrs). Skin and gut T cells are distinct from each other and from lung, lymphoid sites, and blood, while lung T cells share features with lymphoid sites and blood. TCR repertoire analysis shows that, though majority of gut and skin T cell clones are unique to the tissue, expanded clones within these barrier sites share clonal overlap with other barrier and lymphoid sites. Moreover, T cells in the lung exhibit increased sharing with lymphoid sites and blood. Together, these results reveal how human T cells are compartmentalized in the skin and gut through site-specific adaptations while demonstrating that gut, lung, and skin barrier T cells are connected through shared specificities in a network of immune protection across the body." @default.
- W4313373472 created "2023-01-06" @default.
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- W4313373472 date "2020-05-01" @default.
- W4313373472 modified "2023-10-16" @default.
- W4313373472 title "Human T cell immunity in barrier sites is phenotypically distinct but clonally connected to other sites" @default.
- W4313373472 doi "https://doi.org/10.4049/jimmunol.204.supp.235.7" @default.
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