Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373479> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313373479 endingPage "86.45" @default.
- W4313373479 startingPage "86.45" @default.
- W4313373479 abstract "Abstract T cells are the master regulators of adaptive immune responses. Proper T cell responses are essential for the hosts to orchestrate sufficient adaptive immunity. T cell immunity is crucial for anti-tumor immunity. Manipulating T cell immunity by Chinese herbs is a promising field to explore. Many herbs were reported to regulate the T cell activation. Modulation of T cell immunity by Chinese herbs may be an applicable intervention to modulate immunity, for example, to promote anti-tumor immunity against cancer. In this study, we developed a Chinese Herbal Immunogen Assay to measure the T cell immunity by screening the commonly used Chinese herbal formulas and single herbs from our Chinese herbal medicine extracts database. In the preliminary test, we collected human peripheral blood mononuclear cells (PBMC) were from fresh whole heparinized blood of healthy donors or cancer patients to proof the concept. The isolated PBMCs were stimulated with DMSO or a panel of various herbal extracts, respectively. Cytokines secretion from the activated PBMCs in culture supernatants were quantified at various time points by using standard ELISA for TNF-a, IL-6 and IFN-γ. At baseline, PBMCs from cancer patients had a lower average level of TNF-a, IL-6 and IFN-γ, compared to the healthy controls. After stimulation with a panel of herbal extracts, we identified the herbs that can consistently enhance cytokine productions. These herbs could be used for further development of new drug for boosting anti-tumor immunity." @default.
- W4313373479 created "2023-01-06" @default.
- W4313373479 creator A5030166913 @default.
- W4313373479 creator A5040903330 @default.
- W4313373479 date "2020-05-01" @default.
- W4313373479 modified "2023-09-26" @default.
- W4313373479 title "Development of a Chinese Herbal Immunogen Assay for the Measurement of T cell Anti-Tumor Immunity" @default.
- W4313373479 doi "https://doi.org/10.4049/jimmunol.204.supp.86.45" @default.
- W4313373479 hasPublicationYear "2020" @default.
- W4313373479 type Work @default.
- W4313373479 citedByCount "0" @default.
- W4313373479 crossrefType "journal-article" @default.
- W4313373479 hasAuthorship W4313373479A5030166913 @default.
- W4313373479 hasAuthorship W4313373479A5040903330 @default.
- W4313373479 hasConcept C137061746 @default.
- W4313373479 hasConcept C159654299 @default.
- W4313373479 hasConcept C193419808 @default.
- W4313373479 hasConcept C202751555 @default.
- W4313373479 hasConcept C203014093 @default.
- W4313373479 hasConcept C2776090121 @default.
- W4313373479 hasConcept C2778690821 @default.
- W4313373479 hasConcept C2779341262 @default.
- W4313373479 hasConcept C2779909307 @default.
- W4313373479 hasConcept C3017875465 @default.
- W4313373479 hasConcept C542903549 @default.
- W4313373479 hasConcept C55493867 @default.
- W4313373479 hasConcept C556039675 @default.
- W4313373479 hasConcept C71924100 @default.
- W4313373479 hasConcept C86803240 @default.
- W4313373479 hasConcept C8891405 @default.
- W4313373479 hasConceptScore W4313373479C137061746 @default.
- W4313373479 hasConceptScore W4313373479C159654299 @default.
- W4313373479 hasConceptScore W4313373479C193419808 @default.
- W4313373479 hasConceptScore W4313373479C202751555 @default.
- W4313373479 hasConceptScore W4313373479C203014093 @default.
- W4313373479 hasConceptScore W4313373479C2776090121 @default.
- W4313373479 hasConceptScore W4313373479C2778690821 @default.
- W4313373479 hasConceptScore W4313373479C2779341262 @default.
- W4313373479 hasConceptScore W4313373479C2779909307 @default.
- W4313373479 hasConceptScore W4313373479C3017875465 @default.
- W4313373479 hasConceptScore W4313373479C542903549 @default.
- W4313373479 hasConceptScore W4313373479C55493867 @default.
- W4313373479 hasConceptScore W4313373479C556039675 @default.
- W4313373479 hasConceptScore W4313373479C71924100 @default.
- W4313373479 hasConceptScore W4313373479C86803240 @default.
- W4313373479 hasConceptScore W4313373479C8891405 @default.
- W4313373479 hasIssue "1_Supplement" @default.
- W4313373479 hasLocation W43133734791 @default.
- W4313373479 hasOpenAccess W4313373479 @default.
- W4313373479 hasPrimaryLocation W43133734791 @default.
- W4313373479 hasRelatedWork W2090477263 @default.
- W4313373479 hasRelatedWork W2160133043 @default.
- W4313373479 hasRelatedWork W2164219360 @default.
- W4313373479 hasRelatedWork W2223869382 @default.
- W4313373479 hasRelatedWork W2339159816 @default.
- W4313373479 hasRelatedWork W2381196212 @default.
- W4313373479 hasRelatedWork W2422131700 @default.
- W4313373479 hasRelatedWork W2766647135 @default.
- W4313373479 hasRelatedWork W4307359803 @default.
- W4313373479 hasRelatedWork W573847062 @default.
- W4313373479 hasVolume "204" @default.
- W4313373479 isParatext "false" @default.
- W4313373479 isRetracted "false" @default.
- W4313373479 workType "article" @default.