Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373506> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313373506 endingPage "155.16" @default.
- W4313373506 startingPage "155.16" @default.
- W4313373506 abstract "Abstract CD8 T cells are the cytotoxic effectors of the adaptive immune response, clearing virally infected and cancerous cells within the host. CD8 T cells acquire their cytotoxic function by differentiating into cytotoxic T lymphocytes (CTLs). Once the CTLs have cleared the antigen, the majority of responding cells will die during contraction, while a small population of the antigen-specific responders will remain, differentiating into long-lived memory cells that provide potent protection to the host upon re-encounter with the antigen. However, during chronic infection and cancer, CD8 T cells are often diverted into the so-called exhausted state, in which CTLs are losing their function. As such, the ability to program the differentiation of CD8 T cells into a particular lineage is an important therapeutic strategy. We have identified a global post-transcriptional mechanism that directs the fate of differentiating CD8 T cells. Specifically, we have found that let-7 miRNAs are downregulated upon T cell activation, allowing T cells to differentiate into CTLs. Moreover, we have found that prolonged expression of these miRNAs programs CD8 T cells to become memory cells, while complete loss induces exhaustion. Thus, these findings may have important implications for the improvement of current immunotherapies targeting CD8 T cell fate." @default.
- W4313373506 created "2023-01-06" @default.
- W4313373506 creator A5067120645 @default.
- W4313373506 date "2020-05-01" @default.
- W4313373506 modified "2023-09-23" @default.
- W4313373506 title "CD8 T cell fate is programmed by a miRNA-mediated mechanism" @default.
- W4313373506 doi "https://doi.org/10.4049/jimmunol.204.supp.155.16" @default.
- W4313373506 hasPublicationYear "2020" @default.
- W4313373506 type Work @default.
- W4313373506 citedByCount "0" @default.
- W4313373506 crossrefType "journal-article" @default.
- W4313373506 hasAuthorship W4313373506A5067120645 @default.
- W4313373506 hasConcept C129374314 @default.
- W4313373506 hasConcept C147483822 @default.
- W4313373506 hasConcept C154317977 @default.
- W4313373506 hasConcept C167672396 @default.
- W4313373506 hasConcept C202751555 @default.
- W4313373506 hasConcept C203014093 @default.
- W4313373506 hasConcept C2776090121 @default.
- W4313373506 hasConcept C2908647359 @default.
- W4313373506 hasConcept C502942594 @default.
- W4313373506 hasConcept C54355233 @default.
- W4313373506 hasConcept C67662055 @default.
- W4313373506 hasConcept C71924100 @default.
- W4313373506 hasConcept C86803240 @default.
- W4313373506 hasConcept C8891405 @default.
- W4313373506 hasConcept C95444343 @default.
- W4313373506 hasConcept C99454951 @default.
- W4313373506 hasConceptScore W4313373506C129374314 @default.
- W4313373506 hasConceptScore W4313373506C147483822 @default.
- W4313373506 hasConceptScore W4313373506C154317977 @default.
- W4313373506 hasConceptScore W4313373506C167672396 @default.
- W4313373506 hasConceptScore W4313373506C202751555 @default.
- W4313373506 hasConceptScore W4313373506C203014093 @default.
- W4313373506 hasConceptScore W4313373506C2776090121 @default.
- W4313373506 hasConceptScore W4313373506C2908647359 @default.
- W4313373506 hasConceptScore W4313373506C502942594 @default.
- W4313373506 hasConceptScore W4313373506C54355233 @default.
- W4313373506 hasConceptScore W4313373506C67662055 @default.
- W4313373506 hasConceptScore W4313373506C71924100 @default.
- W4313373506 hasConceptScore W4313373506C86803240 @default.
- W4313373506 hasConceptScore W4313373506C8891405 @default.
- W4313373506 hasConceptScore W4313373506C95444343 @default.
- W4313373506 hasConceptScore W4313373506C99454951 @default.
- W4313373506 hasIssue "1_Supplement" @default.
- W4313373506 hasLocation W43133735061 @default.
- W4313373506 hasOpenAccess W4313373506 @default.
- W4313373506 hasPrimaryLocation W43133735061 @default.
- W4313373506 hasRelatedWork W1578871315 @default.
- W4313373506 hasRelatedWork W2006711838 @default.
- W4313373506 hasRelatedWork W2008057646 @default.
- W4313373506 hasRelatedWork W2040729254 @default.
- W4313373506 hasRelatedWork W2139860153 @default.
- W4313373506 hasRelatedWork W2270348304 @default.
- W4313373506 hasRelatedWork W2287738525 @default.
- W4313373506 hasRelatedWork W2366412323 @default.
- W4313373506 hasRelatedWork W4284991688 @default.
- W4313373506 hasRelatedWork W2185606143 @default.
- W4313373506 hasVolume "204" @default.
- W4313373506 isParatext "false" @default.
- W4313373506 isRetracted "false" @default.
- W4313373506 workType "article" @default.