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- W4313373554 abstract "Abstract Pediatric and adolescent patients in need of allogeneic hematopoietic stem cell transplantation (HSCT) generally receive stem cells from older, unrelated or parental donors when a sibling donor is not available. Despite encouraging clinical outcomes, it has been suggested that immune reconstitution accompanied by increased replicative stress and a large difference between donor and recipient age may worsen immunosenescence in pediatric recipients. Therefore, in this study paired samples were collected at the same time from donors and recipients of haploidentical hematopoietic stem cell transplantation (HaploSCT). We then conducted flow cytometry-based phenotypic and functional analyses and telomere length (TL) measurements of 21 paired T-cell sets from parental donors and children who received T cell-replete HaploSCT with post-transplant cyclophosphamide (PTCy). Senescent T cells, CD28− or CD57+ cells, were significantly expanded in patients. Further, not only CD4+CD28− T cells, but also CD4+CD28+ T cells showed reduced cytokine production capacity and impaired polyfunctionality compared with parental donors, whereas their TCR-mediated proliferation capacity was comparable. Of note, the TL in patient T cells was preserved, or even slightly longer, in senescent T cells compared with donor cells. Regression analysis showed that senescent features of CD4+ and CD8+ T cells in patients were influenced by donor age and the frequency of CD28− cells, respectively. Our data suggest that in pediatric HaploSCT, premature immunosenescent changes occur in T cells from parental donors and therefore, long-term immune monitoring should be conducted." @default.
- W4313373554 created "2023-01-06" @default.
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- W4313373554 date "2020-05-01" @default.
- W4313373554 modified "2023-09-27" @default.
- W4313373554 title "Immunosenescent characteristics of T cells in young patients following haploidentical stem cell transplantation from parental donors" @default.
- W4313373554 doi "https://doi.org/10.4049/jimmunol.204.supp.87.26" @default.
- W4313373554 hasPublicationYear "2020" @default.
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