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- W4313373577 startingPage "165.22" @default.
- W4313373577 abstract "Abstract Colorectal cancer (CRC) is one of the most common and critical cancers, hence considerable effort has been focused on the identification of prognostic, diagnostic markers and therapeutic targets for CRC. Meanwhile, CRC is extensively known to be related to DNA methylation. PD-1, also known as CD279, is a cell surface protein encoded by PDCD1 gene which acts as the immune checkpoint to terminate pro-inflammatory response of T cells at the right time. Recently, PD-1 has been reported to be aberrantly overexpressed in multiple cancers, hampering the anti-tumor function of T cells. Monoclonal antibodies (mAb) which target PD-1 have been used as cancer therapy, but there has been limited success with the use of immune checkpoint inhibitors. We investigated the DNA methylation status of normal and tumor tissues of Korean CRC patients by performing the targeted bisulfite sequencing and identified that the promoter CpG island of PDCD1 is significantly hypomethylated in CRC tissue compared to its paired adjacent normal tissue. We have hypothesized the hypomethylation of promoter CpG island of PDCD1 is associated with aberrant expression of PD-1 and promotes immune evasion, eventually, development of CRC. Additionally, we are currently checking the possibility that hypomethylation of promoter CpG island of PDCD1 hinders the therapeutic effects of PD-1 monoclonal antibodies in CRC patients." @default.
- W4313373577 created "2023-01-06" @default.
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- W4313373577 date "2020-05-01" @default.
- W4313373577 modified "2023-09-27" @default.
- W4313373577 title "DNA Hypomethylation of <i>PDCD1</i> Gene in Korean Colorectal Cancer Patients" @default.
- W4313373577 doi "https://doi.org/10.4049/jimmunol.204.supp.165.22" @default.
- W4313373577 hasPublicationYear "2020" @default.
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