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- W4313373612 abstract "Abstract Developing medical countermeasures against emerging infectious diseases remains a challenging task. Ebola virus, Crimean CongoHemorrhagic Fever Virus, and Hantaviruses are ever growing threats on the global landscape. A consortium of worldwide researchers has developed a platform for novel monoclonal antibody discovery. This platform is predicated on the understanding that harvesting antibody sequences from convalescent survivors of previous outbreaks may lead to the most effective treatments for future outbreaks. Utilizing flow cytometric sorting of antigen-specific memory B cells for the elucidation of heavy and light chain sequences, novel biologics were identified and generated for evaluation. Specifically, a cocktail of two monoclonal antibodies was discovered and developed for Sudan virus, Ebolavirus, and Bundibugyo virus. Previously, published antivirals have been virus-specific with no cross reactivity against additional species of virus beyond the original agent. This cocktail of monoclonals neutralized and provided efficacy against infection with each of these viruses in animal models (rodent and non-human primate studies). This cocktail is currently being moved into advanced development and phase I clinical trials. More generally, this successful discovery platform is currently being utilized for developing novel monoclonal treatments for alphaviruses, hantaviruses, arenaviruses and other filoviruses. New data on the development of biologics against these agents will be discussed as well." @default.
- W4313373612 created "2023-01-06" @default.
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- W4313373612 date "2020-05-01" @default.
- W4313373612 modified "2023-09-27" @default.
- W4313373612 title "Antibody therapeutics for emerging infectious diseases: Ebola virus and others" @default.
- W4313373612 doi "https://doi.org/10.4049/jimmunol.204.supp.167.21" @default.
- W4313373612 hasPublicationYear "2020" @default.
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