Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373617> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4313373617 endingPage "167.24" @default.
- W4313373617 startingPage "167.24" @default.
- W4313373617 abstract "Abstract Dengue is an emerging mosquito-borne disease and the use of prophylactic vaccine is still limited. We have previously developed the tetravalent dengue vaccine (rMV-TDV) by a recombinant measles virus (MV) vector expressing envelope protein domain III (ED3). In this study, we used AG129 mice to evaluate the protective and/or pathogenic immune responses induced by rMV-TDV. Immunization of rMV-TDV has induced a significant neutralizing antibody response against all serotypes of DENV, as well as a significant CD4-dependent IFN-γ response biased to DENV-3, compared to the vector controls. After DENV-2 challenge, rMV-TDV-immunized mice showed a significant lower viremia and no increase of inflammatory cytokines comparing to the vector controls, which had a ~100 times higher viremia and a significant increase of IFN-γ and TNF-α 3 days after challenge. A robust DENV-2 specific IFN-γ response detected in rMV-TDV-immunized mice suggested that pre-existing DENV-3 biased T-cell responses didn’t cross-react to DENV-2 but an anamnestic DENV-2 specific T-cell response was recalled. Prior to the challenge, only DENV-3 specific IgG demonstrated a significant higher avidity than other serotypes, whose specific IgG avidity increased after DENV-2 challenge, particular in DENV-1 and -2. However, the passive transfer of rMV-TDV immunized sera plus splenocytes resulted in the higher viremia and the significant increase of inflammatory cytokines in AG129 recipient mice after DENV-2 challenge than the vector control donors did. It suggested that while the immunity by rMV-TDV waned, the potential risks for the severe disease increased. Our data shed the lights on the role of a balanced CD4 T-cell response in the prevention of severe dengue." @default.
- W4313373617 created "2023-01-06" @default.
- W4313373617 creator A5019081389 @default.
- W4313373617 creator A5048905619 @default.
- W4313373617 creator A5077183147 @default.
- W4313373617 date "2020-05-01" @default.
- W4313373617 modified "2023-09-27" @default.
- W4313373617 title "The prevention and augmentation of tetravalent recombinant measles-vectored dengue vaccine in dengue-2 infected AG129 mice" @default.
- W4313373617 doi "https://doi.org/10.4049/jimmunol.204.supp.167.24" @default.
- W4313373617 hasPublicationYear "2020" @default.
- W4313373617 type Work @default.
- W4313373617 citedByCount "0" @default.
- W4313373617 crossrefType "journal-article" @default.
- W4313373617 hasAuthorship W4313373617A5019081389 @default.
- W4313373617 hasAuthorship W4313373617A5048905619 @default.
- W4313373617 hasAuthorship W4313373617A5077183147 @default.
- W4313373617 hasConcept C159047783 @default.
- W4313373617 hasConcept C159654299 @default.
- W4313373617 hasConcept C179223381 @default.
- W4313373617 hasConcept C203014093 @default.
- W4313373617 hasConcept C2776185481 @default.
- W4313373617 hasConcept C2779261636 @default.
- W4313373617 hasConcept C2779308166 @default.
- W4313373617 hasConcept C2779635636 @default.
- W4313373617 hasConcept C533803919 @default.
- W4313373617 hasConcept C71924100 @default.
- W4313373617 hasConceptScore W4313373617C159047783 @default.
- W4313373617 hasConceptScore W4313373617C159654299 @default.
- W4313373617 hasConceptScore W4313373617C179223381 @default.
- W4313373617 hasConceptScore W4313373617C203014093 @default.
- W4313373617 hasConceptScore W4313373617C2776185481 @default.
- W4313373617 hasConceptScore W4313373617C2779261636 @default.
- W4313373617 hasConceptScore W4313373617C2779308166 @default.
- W4313373617 hasConceptScore W4313373617C2779635636 @default.
- W4313373617 hasConceptScore W4313373617C533803919 @default.
- W4313373617 hasConceptScore W4313373617C71924100 @default.
- W4313373617 hasIssue "1_Supplement" @default.
- W4313373617 hasLocation W43133736171 @default.
- W4313373617 hasOpenAccess W4313373617 @default.
- W4313373617 hasPrimaryLocation W43133736171 @default.
- W4313373617 hasRelatedWork W1981895261 @default.
- W4313373617 hasRelatedWork W1997677186 @default.
- W4313373617 hasRelatedWork W2044596346 @default.
- W4313373617 hasRelatedWork W2081356962 @default.
- W4313373617 hasRelatedWork W2086462070 @default.
- W4313373617 hasRelatedWork W2128774144 @default.
- W4313373617 hasRelatedWork W2168704739 @default.
- W4313373617 hasRelatedWork W2803064139 @default.
- W4313373617 hasRelatedWork W2890439823 @default.
- W4313373617 hasRelatedWork W4310476913 @default.
- W4313373617 hasVolume "204" @default.
- W4313373617 isParatext "false" @default.
- W4313373617 isRetracted "false" @default.
- W4313373617 workType "article" @default.