Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373639> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313373639 endingPage "225.16" @default.
- W4313373639 startingPage "225.16" @default.
- W4313373639 abstract "Abstract Introductions Hepatitis B virus (HBV) infection remains a significant health issue worldwide. It is a major cause of cirrhosis, HCC and liver failure. A large number of studies showed that host immune responses are the key factor for HBV clearance and persistence. In here, we investigated the role of NK cells in chronic HBV infections. Methods We compared the expression frequency, and functionality of NKGs and KIRs repertoire on NK cells in 170 samples by multi-colour flow cytometry. To further investigate the functionality of the NK cells, we performed K562 target cell killing assay and cytokine driven perforin released assay. Results The percentage of circulation and liver resident NK cells did not significantly alter in HBV patients compared to the healthy controls (HCs). Enrichment of NK cells was observed in the healthy controls but not in the HBV infected patients. The intracellular expression of Granzyme B was significantly reduced in NK cells derived from HBV-infected patients as compared to HCs. No differences were observed in the expression of NKG2A and NKG2C. Interestingly, the levels of NKG2D was significantly increased in the circulating NK cells of HBV infection but not in the liver resident NK cells. The K562 target cell killing ability and IFN-gamma production correlated with the NKG2D expression, particularly in the HBV patients as compared to HCs. Conclusions Our study demonstrated that NK cells activity and status might play an important role in controlling HBV infection." @default.
- W4313373639 created "2023-01-06" @default.
- W4313373639 creator A5007778905 @default.
- W4313373639 creator A5056031593 @default.
- W4313373639 creator A5088234024 @default.
- W4313373639 date "2020-05-01" @default.
- W4313373639 modified "2023-09-27" @default.
- W4313373639 title "Increased NKG2D expressing NK cells in patients with chronic HBV infection" @default.
- W4313373639 doi "https://doi.org/10.4049/jimmunol.204.supp.225.16" @default.
- W4313373639 hasPublicationYear "2020" @default.
- W4313373639 type Work @default.
- W4313373639 citedByCount "0" @default.
- W4313373639 crossrefType "journal-article" @default.
- W4313373639 hasAuthorship W4313373639A5007778905 @default.
- W4313373639 hasAuthorship W4313373639A5056031593 @default.
- W4313373639 hasAuthorship W4313373639A5088234024 @default.
- W4313373639 hasConcept C129374314 @default.
- W4313373639 hasConcept C154317977 @default.
- W4313373639 hasConcept C159047783 @default.
- W4313373639 hasConcept C167672396 @default.
- W4313373639 hasConcept C171122931 @default.
- W4313373639 hasConcept C183193105 @default.
- W4313373639 hasConcept C202751555 @default.
- W4313373639 hasConcept C203014093 @default.
- W4313373639 hasConcept C2522874641 @default.
- W4313373639 hasConcept C2776062744 @default.
- W4313373639 hasConcept C2776090121 @default.
- W4313373639 hasConcept C2778461978 @default.
- W4313373639 hasConcept C2778867473 @default.
- W4313373639 hasConcept C2780380082 @default.
- W4313373639 hasConcept C2780593183 @default.
- W4313373639 hasConcept C553184892 @default.
- W4313373639 hasConcept C55493867 @default.
- W4313373639 hasConcept C71924100 @default.
- W4313373639 hasConcept C86803240 @default.
- W4313373639 hasConcept C8891405 @default.
- W4313373639 hasConceptScore W4313373639C129374314 @default.
- W4313373639 hasConceptScore W4313373639C154317977 @default.
- W4313373639 hasConceptScore W4313373639C159047783 @default.
- W4313373639 hasConceptScore W4313373639C167672396 @default.
- W4313373639 hasConceptScore W4313373639C171122931 @default.
- W4313373639 hasConceptScore W4313373639C183193105 @default.
- W4313373639 hasConceptScore W4313373639C202751555 @default.
- W4313373639 hasConceptScore W4313373639C203014093 @default.
- W4313373639 hasConceptScore W4313373639C2522874641 @default.
- W4313373639 hasConceptScore W4313373639C2776062744 @default.
- W4313373639 hasConceptScore W4313373639C2776090121 @default.
- W4313373639 hasConceptScore W4313373639C2778461978 @default.
- W4313373639 hasConceptScore W4313373639C2778867473 @default.
- W4313373639 hasConceptScore W4313373639C2780380082 @default.
- W4313373639 hasConceptScore W4313373639C2780593183 @default.
- W4313373639 hasConceptScore W4313373639C553184892 @default.
- W4313373639 hasConceptScore W4313373639C55493867 @default.
- W4313373639 hasConceptScore W4313373639C71924100 @default.
- W4313373639 hasConceptScore W4313373639C86803240 @default.
- W4313373639 hasConceptScore W4313373639C8891405 @default.
- W4313373639 hasIssue "1_Supplement" @default.
- W4313373639 hasLocation W43133736391 @default.
- W4313373639 hasOpenAccess W4313373639 @default.
- W4313373639 hasPrimaryLocation W43133736391 @default.
- W4313373639 hasRelatedWork W118297453 @default.
- W4313373639 hasRelatedWork W1573544128 @default.
- W4313373639 hasRelatedWork W2013028459 @default.
- W4313373639 hasRelatedWork W2047671515 @default.
- W4313373639 hasRelatedWork W2074969559 @default.
- W4313373639 hasRelatedWork W4223440188 @default.
- W4313373639 hasRelatedWork W4285806664 @default.
- W4313373639 hasRelatedWork W4285808922 @default.
- W4313373639 hasRelatedWork W4313373639 @default.
- W4313373639 hasRelatedWork W4317639467 @default.
- W4313373639 hasVolume "204" @default.
- W4313373639 isParatext "false" @default.
- W4313373639 isRetracted "false" @default.
- W4313373639 workType "article" @default.