Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373728> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313373728 endingPage "166.22" @default.
- W4313373728 startingPage "166.22" @default.
- W4313373728 abstract "Abstract Introduction Adenosine is a purine metabolite that acts on its leukocyte receptors to inhibit inflammatory and Th1-polarizing cytokine production. Newborns exhibit lower plasma levels of adenosine deaminase (ADA), an enzyme that metabolizes extracellular adenosine, resulting in elevated plasma adenosine levels and a Th2/anti-inflammatory bias. Humans express two ADA isoforms: ADA1 and ADA2. Characterizing the impact of ontogeny and vaccination on levels of ADA1 and ADA2 may provide insight into mechanisms regulating early life immune development. Methods Newborns were recruited at the MRC Unit-Gambia and randomized to either Hepatitis B (HepB), BCG, or the combination of both vaccines. Plasma was collected at birth (day of life (DOL) 0) and at DOL 1, 3, or 7. Plasma levels of ADA1 and ADA2 were measured by a chromogenic assay. Log-transformed ADA concentrations were compared using ANOVA. Results In this interim analysis, we measured n = 51–53 participants per vaccine group per timepoint. ADA2 activity ex vivo in plasma derived from Gambian newborns increased by median fold changes of 1.6 (control), 1.6 (HepB), 1.5 (BCG), and 1.9 (HepB+BCG) over the first week of life. The changes in ADA2 for all groups were statistically significant over DOL 0. HepB and BCG immunizations were both associated with statistically significant 1.5-fold decrease in ADA1 across the first week of life. Conclusions Neonatal plasma ADA2 activity rises across the first week of life, suggestive of ontogeny-specific changes that promote Th2/anti-inflammatory immune status. Immunization at birth with HepB or BCG may be associated with lower ADA1 across the first week of life. ADA isoforms may be useful biomarkers of immune development and vaccine responses." @default.
- W4313373728 created "2023-01-06" @default.
- W4313373728 creator A5000582936 @default.
- W4313373728 creator A5001314694 @default.
- W4313373728 creator A5004327810 @default.
- W4313373728 creator A5012285098 @default.
- W4313373728 creator A5022962015 @default.
- W4313373728 creator A5034163657 @default.
- W4313373728 creator A5068050214 @default.
- W4313373728 creator A5069576329 @default.
- W4313373728 creator A5078198729 @default.
- W4313373728 creator A5082357489 @default.
- W4313373728 date "2020-05-01" @default.
- W4313373728 modified "2023-09-26" @default.
- W4313373728 title "Effect of ontogeny and vaccination on plasma adenosine deaminase (ADA)-1 and -2 levels across the first week of human life" @default.
- W4313373728 doi "https://doi.org/10.4049/jimmunol.204.supp.166.22" @default.
- W4313373728 hasPublicationYear "2020" @default.
- W4313373728 type Work @default.
- W4313373728 citedByCount "0" @default.
- W4313373728 crossrefType "journal-article" @default.
- W4313373728 hasAuthorship W4313373728A5000582936 @default.
- W4313373728 hasAuthorship W4313373728A5001314694 @default.
- W4313373728 hasAuthorship W4313373728A5004327810 @default.
- W4313373728 hasAuthorship W4313373728A5012285098 @default.
- W4313373728 hasAuthorship W4313373728A5022962015 @default.
- W4313373728 hasAuthorship W4313373728A5034163657 @default.
- W4313373728 hasAuthorship W4313373728A5068050214 @default.
- W4313373728 hasAuthorship W4313373728A5069576329 @default.
- W4313373728 hasAuthorship W4313373728A5078198729 @default.
- W4313373728 hasAuthorship W4313373728A5082357489 @default.
- W4313373728 hasConcept C126322002 @default.
- W4313373728 hasConcept C134018914 @default.
- W4313373728 hasConcept C150903083 @default.
- W4313373728 hasConcept C203014093 @default.
- W4313373728 hasConcept C207001950 @default.
- W4313373728 hasConcept C22070199 @default.
- W4313373728 hasConcept C26291073 @default.
- W4313373728 hasConcept C2776991684 @default.
- W4313373728 hasConcept C34628245 @default.
- W4313373728 hasConcept C71924100 @default.
- W4313373728 hasConcept C86803240 @default.
- W4313373728 hasConcept C8891405 @default.
- W4313373728 hasConceptScore W4313373728C126322002 @default.
- W4313373728 hasConceptScore W4313373728C134018914 @default.
- W4313373728 hasConceptScore W4313373728C150903083 @default.
- W4313373728 hasConceptScore W4313373728C203014093 @default.
- W4313373728 hasConceptScore W4313373728C207001950 @default.
- W4313373728 hasConceptScore W4313373728C22070199 @default.
- W4313373728 hasConceptScore W4313373728C26291073 @default.
- W4313373728 hasConceptScore W4313373728C2776991684 @default.
- W4313373728 hasConceptScore W4313373728C34628245 @default.
- W4313373728 hasConceptScore W4313373728C71924100 @default.
- W4313373728 hasConceptScore W4313373728C86803240 @default.
- W4313373728 hasConceptScore W4313373728C8891405 @default.
- W4313373728 hasIssue "1_Supplement" @default.
- W4313373728 hasLocation W43133737281 @default.
- W4313373728 hasOpenAccess W4313373728 @default.
- W4313373728 hasPrimaryLocation W43133737281 @default.
- W4313373728 hasRelatedWork W1978639835 @default.
- W4313373728 hasRelatedWork W2017770252 @default.
- W4313373728 hasRelatedWork W2038565054 @default.
- W4313373728 hasRelatedWork W2056270585 @default.
- W4313373728 hasRelatedWork W206302104 @default.
- W4313373728 hasRelatedWork W2130981205 @default.
- W4313373728 hasRelatedWork W2265156150 @default.
- W4313373728 hasRelatedWork W2284240597 @default.
- W4313373728 hasRelatedWork W2320914227 @default.
- W4313373728 hasRelatedWork W2398262967 @default.
- W4313373728 hasVolume "204" @default.
- W4313373728 isParatext "false" @default.
- W4313373728 isRetracted "false" @default.
- W4313373728 workType "article" @default.