Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373744> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313373744 endingPage "229.2" @default.
- W4313373744 startingPage "229.2" @default.
- W4313373744 abstract "Abstract High endothelial venules (HEVs), which are characterized by the expression of peripheral node addressin (PNAd), are essential routes for the trafficking of naïve T cells and central memory T cells (Tcms) into secondary lymphoid organs. In lymph nodes (LNs), lymphotoxin (LT) α1β2-LTβ receptor (LTβR) signaling from dendritic cells (DCs) is essential for the formation of HEVs. Although it has been reported that PNAd+ HEV-like vessels appear in the skin under some inflammatory condition, such as atopic dermatitis (AD), the formation mechanism of HEV-like vessels and their functions in the skin have remained unclear. To clarify these issues, we established a system to induce PNAd+ HEV-like vessels in the skin, using a mouse AD model induced by calcipotriol. Flow cytometric (FCM) analysis revealed that around 20–30% of vessels were PNAd+ in the AD-like skin lesions. Electron microscopic analysis showed prominent formation of rough endoplasmic reticulum, Golgi apparatus and mitochondria in the HEV-like vessels similar to HEVs in LNs. These vessels were mainly detected in post-capillary venules, around which dermal DCs formed clusters. Administration of LTβR-Fc fusion protein or inhibition of the DC clusters by either pertussis toxin or depletion of DCs using CD11c diphtheria toxin receptor transgenic mice abolished the formation of HEV-like vessels in the skin. Naïve T cells and Tcms infiltration were detected in both AD patients and murine AD model skin by immunohistochemistry and FCM. Collectively, our results suggest that LTβR signaling and CD11c+ DCs mediate the formation of HEV-like vessels in the skin, which may possess functions of HEV and regulate the transmigration of naïve T cells and Tcms." @default.
- W4313373744 created "2023-01-06" @default.
- W4313373744 creator A5019730291 @default.
- W4313373744 creator A5023306899 @default.
- W4313373744 creator A5048762693 @default.
- W4313373744 creator A5050440940 @default.
- W4313373744 date "2020-05-01" @default.
- W4313373744 modified "2023-09-27" @default.
- W4313373744 title "Lymphotoxin β receptor signaling and CD11c-positive dendritic cells form high endothelial venule-like vessels in the skin in murine atopic dermatitis model" @default.
- W4313373744 doi "https://doi.org/10.4049/jimmunol.204.supp.229.2" @default.
- W4313373744 hasPublicationYear "2020" @default.
- W4313373744 type Work @default.
- W4313373744 citedByCount "0" @default.
- W4313373744 crossrefType "journal-article" @default.
- W4313373744 hasAuthorship W4313373744A5019730291 @default.
- W4313373744 hasAuthorship W4313373744A5023306899 @default.
- W4313373744 hasAuthorship W4313373744A5048762693 @default.
- W4313373744 hasAuthorship W4313373744A5050440940 @default.
- W4313373744 hasConcept C104317684 @default.
- W4313373744 hasConcept C127716648 @default.
- W4313373744 hasConcept C142724271 @default.
- W4313373744 hasConcept C181152851 @default.
- W4313373744 hasConcept C203014093 @default.
- W4313373744 hasConcept C2778170410 @default.
- W4313373744 hasConcept C2779720271 @default.
- W4313373744 hasConcept C2779919695 @default.
- W4313373744 hasConcept C2780385752 @default.
- W4313373744 hasConcept C49773422 @default.
- W4313373744 hasConcept C55493867 @default.
- W4313373744 hasConcept C61879462 @default.
- W4313373744 hasConcept C62478195 @default.
- W4313373744 hasConcept C71924100 @default.
- W4313373744 hasConcept C80631254 @default.
- W4313373744 hasConcept C86803240 @default.
- W4313373744 hasConcept C8891405 @default.
- W4313373744 hasConcept C95444343 @default.
- W4313373744 hasConceptScore W4313373744C104317684 @default.
- W4313373744 hasConceptScore W4313373744C127716648 @default.
- W4313373744 hasConceptScore W4313373744C142724271 @default.
- W4313373744 hasConceptScore W4313373744C181152851 @default.
- W4313373744 hasConceptScore W4313373744C203014093 @default.
- W4313373744 hasConceptScore W4313373744C2778170410 @default.
- W4313373744 hasConceptScore W4313373744C2779720271 @default.
- W4313373744 hasConceptScore W4313373744C2779919695 @default.
- W4313373744 hasConceptScore W4313373744C2780385752 @default.
- W4313373744 hasConceptScore W4313373744C49773422 @default.
- W4313373744 hasConceptScore W4313373744C55493867 @default.
- W4313373744 hasConceptScore W4313373744C61879462 @default.
- W4313373744 hasConceptScore W4313373744C62478195 @default.
- W4313373744 hasConceptScore W4313373744C71924100 @default.
- W4313373744 hasConceptScore W4313373744C80631254 @default.
- W4313373744 hasConceptScore W4313373744C86803240 @default.
- W4313373744 hasConceptScore W4313373744C8891405 @default.
- W4313373744 hasConceptScore W4313373744C95444343 @default.
- W4313373744 hasIssue "1_Supplement" @default.
- W4313373744 hasLocation W43133737441 @default.
- W4313373744 hasOpenAccess W4313373744 @default.
- W4313373744 hasPrimaryLocation W43133737441 @default.
- W4313373744 hasRelatedWork W1973988310 @default.
- W4313373744 hasRelatedWork W2020026448 @default.
- W4313373744 hasRelatedWork W2056397146 @default.
- W4313373744 hasRelatedWork W2133635174 @default.
- W4313373744 hasRelatedWork W2406011238 @default.
- W4313373744 hasRelatedWork W3134048471 @default.
- W4313373744 hasRelatedWork W3161107101 @default.
- W4313373744 hasRelatedWork W4205548131 @default.
- W4313373744 hasRelatedWork W4313373744 @default.
- W4313373744 hasRelatedWork W4313385397 @default.
- W4313373744 hasVolume "204" @default.
- W4313373744 isParatext "false" @default.
- W4313373744 isRetracted "false" @default.
- W4313373744 workType "article" @default.