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- W4313373757 abstract "Abstract Previous studies have been performed using vaccine viruses attenuated by genetic disruption of key regulatory genes. The moderately attenuated prototypic vaccine strain SIVmac239Δnef has been used in most studies; however, it does not provide sufficient effects to prevent infection. Ag85B is one of the most dominant proteins secreted from most mycobacterial species. It has been shown to induce substantial Th1 cell proliferation and vigorous Th1 cytokine production. In the present study, we genetically constructed a live nef-deleted simian human immunodeficiency virus to express the adjuvant molecule Ag85B (SHIV-Ag85B) and assessed vaccine effects in cynomolgus macaques. SHIV-Ag85B could not be detected at 4 weeks after injection in cynomolgus macaques. When these macaques in which SHIV-Ag85B had become undetectable were challenged with pathogenic SHIV89.6P at 37 weeks after SHIV-Ag85B became undetectable, SHIV89.6P could not be detected at 36 weeks after the challenge in most of the macaques. In these macaques, SHIV antigen-specific CD8+ T cell responses with polyfunctionality were rapidly induced after SHIV89.6P injection. Eradication of pathogenic SHIV89.6P was confirmed by adoptive transfer experiments and CD8+ cell depletion study. These results suggest that SHIV-Ag85B elicited viral antigen-specific CD8+ T cell responses against pathogenic SHIV and provide the possibility of eradicating a pathogenic lentivirus from the infected cells. The results of this study provide further insights into the containment of HIV infections as well as new opportunities to develop a better therapeutic vaccines and cure." @default.
- W4313373757 created "2023-01-06" @default.
- W4313373757 creator A5077677935 @default.
- W4313373757 date "2020-05-01" @default.
- W4313373757 modified "2023-09-27" @default.
- W4313373757 title "Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus" @default.
- W4313373757 doi "https://doi.org/10.4049/jimmunol.204.supp.167.7" @default.
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