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- W4313373818 startingPage "227.22" @default.
- W4313373818 abstract "Abstract Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a human pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome (HUS). Shiga toxin (Stx), the primary virulence factor of EHEC, mediates much of the morbidity and mortality associated with EHEC infection. Although Stx is well characterized in terms of its toxic activity, it is not clear if Stx has a specific role in immune cells during EHEC infection. In this study, we identified an inflammasome inhibitory role for Stx during EHEC infection. Stx specifically suppressed the activation of caspase-11-mediated cytosolic LPS sensing pathway in macrophages and mice. Stx did not inhibit the production of inflammasome-independent cytokines, TNF and IL-6. Similarly, Stx did not impair the activation of AIM2, NLRC4, or the canonical NLRP3 inflammasomes. Multiples subtypes of stx were able to suppress the caspase-11-mediated inflammasome responses. Stx was also capable of suppressing inflammasome responses induced by intraperitoneal injection of LPS as well as by Citrobacter rodentium infection in mice. Together, these data reveal that Stx plays an important role in overcoming inflammasome responses during EHEC infection." @default.
- W4313373818 created "2023-01-06" @default.
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- W4313373818 date "2020-05-01" @default.
- W4313373818 modified "2023-09-27" @default.
- W4313373818 title "Suppression of caspase-11-mediated cytosolic LPS sensing pathway by Shiga toxin" @default.
- W4313373818 doi "https://doi.org/10.4049/jimmunol.204.supp.227.22" @default.
- W4313373818 hasPublicationYear "2020" @default.
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