Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374447> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313374447 endingPage "76.7" @default.
- W4313374447 startingPage "76.7" @default.
- W4313374447 abstract "Abstract Protein Arginine Methyltransferase (PRMT) 5 is an enzyme catalyzing symmetric dimethylation (SDM) of arginine. This post-translational modification is known to be involved in oncogenesis and embryonic development. Our previous work has shown that PRMT5 is induced during T cell activation. However, the role and mechanisms by which PRMT5 modulates T helper (Th) cell polarization and autoimmune disease have not yet been elucidated. To study the impact of PRMT5 on gene expression programs induced in activated T cells, we developed a conditional PRMT5 knockout (KO) mouse model in which PRMT5 deletion can be induced in CD4+ T cells after thymic development and performed RNA sequencing (RNAseq) analyses in 3-day activated naïve CD4 T cells. We found that PRMT5 promoted expression of cholesterol biosynthetic pathway enzymes that produce Retinoid-Related Orphan Receptor (ROR) agonists that activate ROR-gt and promote Th17 differentiation. Indeed, Th17 differentiation was blunted in PRMT5 KO T cells. Finally, we identify the cholesterol biosynthesis pathway regulator SREBP-1 as a target of PRMT5 SDM. This work shows that PRMT5 expression in activated T cells is needed for the cholesterol biosynthesis gene expression program, generating ROR-gt agonistic activity and promoting Th17 differentiation. These results point to T cell PRMT5 and the downstream cholesterol biosynthesis pathway as promising therapeutic targets in Th17 cell-based diseases." @default.
- W4313374447 created "2023-01-06" @default.
- W4313374447 creator A5000336280 @default.
- W4313374447 creator A5039568881 @default.
- W4313374447 creator A5066929256 @default.
- W4313374447 creator A5090059379 @default.
- W4313374447 creator A5090283584 @default.
- W4313374447 date "2020-05-01" @default.
- W4313374447 modified "2023-09-27" @default.
- W4313374447 title "Role of PRMT5 in cholesterol metabolism and Th17 pathogenicity" @default.
- W4313374447 doi "https://doi.org/10.4049/jimmunol.204.supp.76.7" @default.
- W4313374447 hasPublicationYear "2020" @default.
- W4313374447 type Work @default.
- W4313374447 citedByCount "0" @default.
- W4313374447 crossrefType "journal-article" @default.
- W4313374447 hasAuthorship W4313374447A5000336280 @default.
- W4313374447 hasAuthorship W4313374447A5039568881 @default.
- W4313374447 hasAuthorship W4313374447A5066929256 @default.
- W4313374447 hasAuthorship W4313374447A5090059379 @default.
- W4313374447 hasAuthorship W4313374447A5090283584 @default.
- W4313374447 hasConcept C104317684 @default.
- W4313374447 hasConcept C111819275 @default.
- W4313374447 hasConcept C185592680 @default.
- W4313374447 hasConcept C33288867 @default.
- W4313374447 hasConcept C55493867 @default.
- W4313374447 hasConcept C74737994 @default.
- W4313374447 hasConcept C86339819 @default.
- W4313374447 hasConcept C86803240 @default.
- W4313374447 hasConcept C91965660 @default.
- W4313374447 hasConcept C95444343 @default.
- W4313374447 hasConceptScore W4313374447C104317684 @default.
- W4313374447 hasConceptScore W4313374447C111819275 @default.
- W4313374447 hasConceptScore W4313374447C185592680 @default.
- W4313374447 hasConceptScore W4313374447C33288867 @default.
- W4313374447 hasConceptScore W4313374447C55493867 @default.
- W4313374447 hasConceptScore W4313374447C74737994 @default.
- W4313374447 hasConceptScore W4313374447C86339819 @default.
- W4313374447 hasConceptScore W4313374447C86803240 @default.
- W4313374447 hasConceptScore W4313374447C91965660 @default.
- W4313374447 hasConceptScore W4313374447C95444343 @default.
- W4313374447 hasIssue "1_Supplement" @default.
- W4313374447 hasLocation W43133744471 @default.
- W4313374447 hasOpenAccess W4313374447 @default.
- W4313374447 hasPrimaryLocation W43133744471 @default.
- W4313374447 hasRelatedWork W2032623135 @default.
- W4313374447 hasRelatedWork W2034379669 @default.
- W4313374447 hasRelatedWork W2751282779 @default.
- W4313374447 hasRelatedWork W2791623992 @default.
- W4313374447 hasRelatedWork W2792405262 @default.
- W4313374447 hasRelatedWork W2910327215 @default.
- W4313374447 hasRelatedWork W2922854582 @default.
- W4313374447 hasRelatedWork W2988905850 @default.
- W4313374447 hasRelatedWork W2995805737 @default.
- W4313374447 hasRelatedWork W3197126452 @default.
- W4313374447 hasVolume "204" @default.
- W4313374447 isParatext "false" @default.
- W4313374447 isRetracted "false" @default.
- W4313374447 workType "article" @default.