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- W4313374464 abstract "Abstract Anergy is critical for silencing autoreactive B cells and preventing autoimmune diseases. Very little is known about the induction and maintenance of anergic B cells within atherosclerosis. To assess the role of B cell anergy in atherosclerosis, we decided to use the Ars/A1 transgenic model, where anergic B cells express receptors that bind to self-antigen and hapten p-azophenylarsonate (Ars). To further differentiate the role of anergy versus BCR signaling we used MD4 mice, which respond normally to antigen, but have a transgenic BCR specific for hen egg lysosome. Ars/A1, MD4, and BL/6 littermate controls were injected with AAV-PCSK9 to increase circulating cholesterol levels and fed a western diet (WD) for 16 weeks. While there were no significant differences in weight or total plasma cholesterol levels, Ars/A1 mice had a significant decrease in plaque burden compared to littermate controls. Interestingly we observed an increase in B-regulatory cells in Ars/A1 mice compared to BL/6 and MD4 mice. With recent reports suggesting that anergic B cells dampen the overall immune response our data suggests that anergy and not B cell signaling is the important mechanism of controlling the inflammatory environment in atherosclerosis." @default.
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- W4313374464 date "2020-05-01" @default.
- W4313374464 modified "2023-09-27" @default.
- W4313374464 title "The protective role of B cell anergy in the development of Atherosclerosis" @default.
- W4313374464 doi "https://doi.org/10.4049/jimmunol.204.supp.71.13" @default.
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