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- W4313374468 abstract "Abstract Intestinal intraepithelial T cells (IETs) provide a first line of defense against intestinal pathogens and play an important role in immune tolerance versus activation. In pigs, intestinal T cell populations stabilize at ~8 weeks of age, but IET phenotypes and function are poorly understood during the early postnatal period. Better understanding age- and location-dependent characteristics of porcine IETs may be useful in developing strategies to maintain intestinal integrity and improve health. To assess impacts of age and intestinal location on abundance and composition of IETs, sections of jejunum, ileum, cecum, and colon from 4-, 6-, and 8-week-old pigs were analyzed by histologic staining and flow cytometric analyses. IET abundance increased with age, and CD2+CD8α+γδ and CD4−CD8α+αβ T cells were the primary IET populationsin all samples (>78%). Compositions of IETs were similar at all locations in 4-week-old pigs. As pigs aged, cecal and colonic IET compositions remained similar to each other but diverged from small intestinal IETs, while jejunal and ileal IET compositions diverged from both large intestinal IETs and each other. These findings indicate both intestinal location and age are drivers of IET heterogeneity. Small intestinal IETs had lower percentages of γδ IETs in 6- and 8-week-old pigs, and CD4−CD8α+αβ IETs increased in abundance at all intestinal locations as pigs aged. Percentages of CD27+IETs in ileum and large intestine decreased over time, but decreases were more drastic in large intestine, suggesting IETs in the distal but not proximal intestinal tract were activated as pigs aged. Small intestinal IET compositions closely resembled human IET populations, highlighting pigs as a biomedical model for IET research." @default.
- W4313374468 created "2023-01-06" @default.
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- W4313374468 date "2020-05-01" @default.
- W4313374468 modified "2023-09-25" @default.
- W4313374468 title "Intraepithelial T cell phenotype and function diverge by intestinal location with age" @default.
- W4313374468 doi "https://doi.org/10.4049/jimmunol.204.supp.92.16" @default.
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