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- W4313374472 abstract "Abstract Understanding the underlying determinants of cross-reactive and weakly neutralizing antibody response in dengue virus infection will facilitate the rational development of vaccines and therapeutics. Accordingly, we investigated CD4 T cell subsets in promoting the antibody development in dengue. In longitudinal and antigen-specific analysis we demonstrate the existence of a CXCR5−PD1+ T helper (Th)-subset that co-expresses PD1/ICOS and expands robustly in dengue with warning sign and severe dengue. The magnitude of CXCR5− PD1+ Th-subset is significantly higher than the frequency of activated Tfh cells in dengue. Interestingly, this PD1+/ICOS+ phenotype is exclusively enriched in the DENV-specific CXCR3 expressing Th population. Moreover, the CXCR5−PD1+ Th-subset harbors the potential of B-cell help in terms of expressing key help factors; IL21, CD40L, IL10 and IFNγ. We further demonstrate that IgG responses to NS1 are independent of germinal center (GC) reaction and that CXCR5−PD1+ Th-subset is superior to Tfh subset in inducing plasma cell differentiation and NS1-specific IgG in autologous T-B co-cultures. The targeted gene expression analysis and antigen stimulation assay confirms unique traits in CXCR5−PD1+ Th-subset over the conventional Tfh cells in dengue. Targeting this unique CXCR5−PD1+ Th-subset might limit the excessive differentiation of plasma cells and shape the optimal antibody responses in dengue virus infection." @default.
- W4313374472 created "2023-01-06" @default.
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- W4313374472 date "2020-05-01" @default.
- W4313374472 modified "2023-09-27" @default.
- W4313374472 title "A CXCR5−PD1+ T helper subset triggers excessive plasma cell differentiation and antibody responses in dengue" @default.
- W4313374472 doi "https://doi.org/10.4049/jimmunol.204.supp.247.23" @default.
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