Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374482> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313374482 endingPage "69.23" @default.
- W4313374482 startingPage "69.23" @default.
- W4313374482 abstract "Abstract Excess lipid burden within macrophages disrupts cellular metabolism and alters their cellular function allowing these macrophages to contribute to both inappropriate and/or unresolving inflammation. The molecular mechanisms that align lipid metabolism to macrophage function are not well understood. Lipin-1 is a phosphatidic acid phosphatase that regulates the penultimate step of glycerolipid metabolism. Lipin-1 is also a transcriptional coregulator that regulates the expression of lipid catabolism genes including beta-oxidation. We and others have demonstrated that lipin-1 promotes macrophage pro-inflammatory responses. The objective of this study was to determine the contribution of lipin-1 transcriptional coregulator function within macrophages activity. We used mice that lack either lipin-1 enzymatic activity or both lipin-1 functions in myeloid cells to define how lipin-1 transcriptional coregulator function contributes to macrophage function. We demonstrated that lipin-1 transcriptional coregulator function is required for IL-4 mediated macrophage polarization and effective efferocytosis through the promotion of beta-oxidation/oxidative phosphorylation via activation of PPARγ. Loss of both lipin-1 activities from myeloid cells leads to increased atherosclerotic burden and reduction in wound closure. Furthermore, we observed enhanced pro-inflammatory responses both in the plaques and the serum of atherosclerotic mice lacking myeloid associated lipin-1. Our work provides evidence that lipin-1 aligns cellular lipid metabolism to promote effective macrophage responses." @default.
- W4313374482 created "2023-01-06" @default.
- W4313374482 creator A5002840203 @default.
- W4313374482 creator A5011889982 @default.
- W4313374482 creator A5012428101 @default.
- W4313374482 creator A5012554174 @default.
- W4313374482 creator A5057879870 @default.
- W4313374482 date "2020-05-01" @default.
- W4313374482 modified "2023-09-27" @default.
- W4313374482 title "Lipin-1 coordinates macrophage lipid metabolism to allow macrophage wound healing function" @default.
- W4313374482 doi "https://doi.org/10.4049/jimmunol.204.supp.69.23" @default.
- W4313374482 hasPublicationYear "2020" @default.
- W4313374482 type Work @default.
- W4313374482 citedByCount "0" @default.
- W4313374482 crossrefType "journal-article" @default.
- W4313374482 hasAuthorship W4313374482A5002840203 @default.
- W4313374482 hasAuthorship W4313374482A5011889982 @default.
- W4313374482 hasAuthorship W4313374482A5012428101 @default.
- W4313374482 hasAuthorship W4313374482A5012554174 @default.
- W4313374482 hasAuthorship W4313374482A5057879870 @default.
- W4313374482 hasConcept C14036430 @default.
- W4313374482 hasConcept C185592680 @default.
- W4313374482 hasConcept C202751555 @default.
- W4313374482 hasConcept C203014093 @default.
- W4313374482 hasConcept C2776682551 @default.
- W4313374482 hasConcept C2776914184 @default.
- W4313374482 hasConcept C2779244956 @default.
- W4313374482 hasConcept C2910375186 @default.
- W4313374482 hasConcept C4733338 @default.
- W4313374482 hasConcept C55493867 @default.
- W4313374482 hasConcept C62231903 @default.
- W4313374482 hasConcept C86803240 @default.
- W4313374482 hasConcept C95444343 @default.
- W4313374482 hasConcept C96942376 @default.
- W4313374482 hasConceptScore W4313374482C14036430 @default.
- W4313374482 hasConceptScore W4313374482C185592680 @default.
- W4313374482 hasConceptScore W4313374482C202751555 @default.
- W4313374482 hasConceptScore W4313374482C203014093 @default.
- W4313374482 hasConceptScore W4313374482C2776682551 @default.
- W4313374482 hasConceptScore W4313374482C2776914184 @default.
- W4313374482 hasConceptScore W4313374482C2779244956 @default.
- W4313374482 hasConceptScore W4313374482C2910375186 @default.
- W4313374482 hasConceptScore W4313374482C4733338 @default.
- W4313374482 hasConceptScore W4313374482C55493867 @default.
- W4313374482 hasConceptScore W4313374482C62231903 @default.
- W4313374482 hasConceptScore W4313374482C86803240 @default.
- W4313374482 hasConceptScore W4313374482C95444343 @default.
- W4313374482 hasConceptScore W4313374482C96942376 @default.
- W4313374482 hasIssue "1_Supplement" @default.
- W4313374482 hasLocation W43133744821 @default.
- W4313374482 hasOpenAccess W4313374482 @default.
- W4313374482 hasPrimaryLocation W43133744821 @default.
- W4313374482 hasRelatedWork W2232091405 @default.
- W4313374482 hasRelatedWork W2617671967 @default.
- W4313374482 hasRelatedWork W2807055701 @default.
- W4313374482 hasRelatedWork W2950337984 @default.
- W4313374482 hasRelatedWork W3023903717 @default.
- W4313374482 hasRelatedWork W4200459651 @default.
- W4313374482 hasRelatedWork W4220966087 @default.
- W4313374482 hasRelatedWork W4303184312 @default.
- W4313374482 hasRelatedWork W4317929308 @default.
- W4313374482 hasRelatedWork W3118621835 @default.
- W4313374482 hasVolume "204" @default.
- W4313374482 isParatext "false" @default.
- W4313374482 isRetracted "false" @default.
- W4313374482 workType "article" @default.