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- W4313374498 abstract "Abstract The diversity of human antigen-experienced (CD45RA−) CD4+ T cells in the blood has not been fully elucidated. Using single cells RNA-seq and high-dimensional single-cell mass cytometry (CyTOF), we identified eight distinct populations of CD45RA−CD4+ T cells in peripheral blood of healthy donors. In addition to Tregs and established Th lineages, we also identified a distinct population of T cells that expressed GM-CSF, but lacked expression of master transcription factors and signature cytokines of other Th cell lineages. These cells, which we tentatively designated “ThG”, co-expressed GM-CSF, IL-2, TNF, IL-3 and CCL20. ThG cells had a stable phenotype and were highly encephalitogenic. Similar to Th17 cells, ThG cells switched their phenotype to Th1 in response to IL-12. T-bet was not required for ThG development, but it was required for their encephalitogenicity. Analogous to other Th cells, ThG cells had a tendency to eventually cease GM-CSF expression without other major changes in their phenotype, which clearly opens the possibility that GM-CSF− ThG cells actually exist." @default.
- W4313374498 created "2023-01-06" @default.
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- W4313374498 date "2020-05-01" @default.
- W4313374498 modified "2023-09-27" @default.
- W4313374498 title "ThG cells: a distinct T helper cell subset expressing GM-CSF, TNF, and IL-2, but not Th lineage-specific cytokines" @default.
- W4313374498 doi "https://doi.org/10.4049/jimmunol.204.supp.58.7" @default.
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