Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374504> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313374504 endingPage "89.9" @default.
- W4313374504 startingPage "89.9" @default.
- W4313374504 abstract "Abstract Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) infection and can be treated by adoptive transfer of EBV-specific T cells. Although EBV-specific T cell immune response has been identified in NPC, the phenotype and functionality of EBV-specific, tissue-resident memory T cells has not been explored. Tumor-infiltrating lymphocytes (TILs) were isolated from newly-diagnosed NPC and two types of EBV-unrelated malignancies; oral squamous cell carcinoma (OSCC) and renal cell carcinoma (RCC) tissue samples. We found that endogenous EBV-specific T cell response can be detected in the all the tissue types, including NPC, OSCC and RCC, but were rare in peripheral blood. In all tissues, EBV-specific T cells in tumor tissues exhibit resident memory phenotype characterized by high CD69 and CD103 expression and also an exhaustion phenotype characterized by high CD39 and PD-1 expression. Unexpectedly, EBV-specific T cell frequency as well as response magnitude were not enhanced in NPC when compared to other tissue types. The lack of an enhanced EBV-specific T cell response magnitude in NPC tissue confirms the concept that enhancement of EBV-specific immunity by adoptive T cell therapy may improve the outcome of NPC." @default.
- W4313374504 created "2023-01-06" @default.
- W4313374504 creator A5025098412 @default.
- W4313374504 creator A5033920254 @default.
- W4313374504 creator A5075186202 @default.
- W4313374504 creator A5075967308 @default.
- W4313374504 creator A5091839516 @default.
- W4313374504 date "2020-05-01" @default.
- W4313374504 modified "2023-09-27" @default.
- W4313374504 title "Polyfunctional endogenous EBV-specific T cell response in nasopharyngeal carcinoma" @default.
- W4313374504 doi "https://doi.org/10.4049/jimmunol.204.supp.89.9" @default.
- W4313374504 hasPublicationYear "2020" @default.
- W4313374504 type Work @default.
- W4313374504 citedByCount "0" @default.
- W4313374504 crossrefType "journal-article" @default.
- W4313374504 hasAuthorship W4313374504A5025098412 @default.
- W4313374504 hasAuthorship W4313374504A5033920254 @default.
- W4313374504 hasAuthorship W4313374504A5075186202 @default.
- W4313374504 hasAuthorship W4313374504A5075967308 @default.
- W4313374504 hasAuthorship W4313374504A5091839516 @default.
- W4313374504 hasConcept C126322002 @default.
- W4313374504 hasConcept C142724271 @default.
- W4313374504 hasConcept C1491633281 @default.
- W4313374504 hasConcept C203014093 @default.
- W4313374504 hasConcept C2522874641 @default.
- W4313374504 hasConcept C2776090121 @default.
- W4313374504 hasConcept C2777546739 @default.
- W4313374504 hasConcept C2778997737 @default.
- W4313374504 hasConcept C2781375147 @default.
- W4313374504 hasConcept C502942594 @default.
- W4313374504 hasConcept C509974204 @default.
- W4313374504 hasConcept C54355233 @default.
- W4313374504 hasConcept C71924100 @default.
- W4313374504 hasConcept C86803240 @default.
- W4313374504 hasConcept C8891405 @default.
- W4313374504 hasConcept C90375314 @default.
- W4313374504 hasConceptScore W4313374504C126322002 @default.
- W4313374504 hasConceptScore W4313374504C142724271 @default.
- W4313374504 hasConceptScore W4313374504C1491633281 @default.
- W4313374504 hasConceptScore W4313374504C203014093 @default.
- W4313374504 hasConceptScore W4313374504C2522874641 @default.
- W4313374504 hasConceptScore W4313374504C2776090121 @default.
- W4313374504 hasConceptScore W4313374504C2777546739 @default.
- W4313374504 hasConceptScore W4313374504C2778997737 @default.
- W4313374504 hasConceptScore W4313374504C2781375147 @default.
- W4313374504 hasConceptScore W4313374504C502942594 @default.
- W4313374504 hasConceptScore W4313374504C509974204 @default.
- W4313374504 hasConceptScore W4313374504C54355233 @default.
- W4313374504 hasConceptScore W4313374504C71924100 @default.
- W4313374504 hasConceptScore W4313374504C86803240 @default.
- W4313374504 hasConceptScore W4313374504C8891405 @default.
- W4313374504 hasConceptScore W4313374504C90375314 @default.
- W4313374504 hasIssue "1_Supplement" @default.
- W4313374504 hasLocation W43133745041 @default.
- W4313374504 hasOpenAccess W4313374504 @default.
- W4313374504 hasPrimaryLocation W43133745041 @default.
- W4313374504 hasRelatedWork W1967903967 @default.
- W4313374504 hasRelatedWork W1970577211 @default.
- W4313374504 hasRelatedWork W1981201050 @default.
- W4313374504 hasRelatedWork W2001761244 @default.
- W4313374504 hasRelatedWork W2071170199 @default.
- W4313374504 hasRelatedWork W2080938068 @default.
- W4313374504 hasRelatedWork W2416019078 @default.
- W4313374504 hasRelatedWork W2939210210 @default.
- W4313374504 hasRelatedWork W42091549 @default.
- W4313374504 hasRelatedWork W4313374504 @default.
- W4313374504 hasVolume "204" @default.
- W4313374504 isParatext "false" @default.
- W4313374504 isRetracted "false" @default.
- W4313374504 workType "article" @default.