Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374518> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313374518 endingPage "59.33" @default.
- W4313374518 startingPage "59.33" @default.
- W4313374518 abstract "Abstract Francisella tularensis is a pathogenic species and a causative agent of tularemia. This bacterium is incredibly infectious and often lethal in that F. tularensis causes the overproduction of pro-inflammatory cytokines. The objective of this study is to identify the innate immune receptors responsible for the production of inflammatory cytokines in response to F. tularensis infection. The study uses an immortalized C57BL/6 Bone Marrow Macrophage (BMMac) cell line as the control and knockout BMMac that are deficient in various innate immune receptors. The cells are passaged and seeded before infecting them with F. tularensis for 2 hours. The cells are treated with a high dose of gentamicin for 2 hours followed by a low dose of gentamicin for an incubation period of 24 hours. The supernatant from these cells are then collected and analysis processed by ELISA, an enzyme-linked immunosorbent assay, to measure production of inflammatory cytokines. These data were compared with the positive control of wild type BMMac and the negative control of uninfected BMMac cells. Analysis of these mutants reveal the involvement of innate immune receptors in triggering the pro-inflammatory cytokine storm in response to F. tularensis infection that leads to death of the host." @default.
- W4313374518 created "2023-01-06" @default.
- W4313374518 creator A5023450714 @default.
- W4313374518 creator A5037058834 @default.
- W4313374518 creator A5084702122 @default.
- W4313374518 date "2020-05-01" @default.
- W4313374518 modified "2023-10-16" @default.
- W4313374518 title "Identifying innate immune receptors causing production of inflammatory cytokines by infection of <i>Francisella tularensis</i>" @default.
- W4313374518 doi "https://doi.org/10.4049/jimmunol.204.supp.59.33" @default.
- W4313374518 hasPublicationYear "2020" @default.
- W4313374518 type Work @default.
- W4313374518 citedByCount "0" @default.
- W4313374518 crossrefType "journal-article" @default.
- W4313374518 hasAuthorship W4313374518A5023450714 @default.
- W4313374518 hasAuthorship W4313374518A5037058834 @default.
- W4313374518 hasAuthorship W4313374518A5084702122 @default.
- W4313374518 hasConcept C104317684 @default.
- W4313374518 hasConcept C136449434 @default.
- W4313374518 hasConcept C142724271 @default.
- W4313374518 hasConcept C170493617 @default.
- W4313374518 hasConcept C202751555 @default.
- W4313374518 hasConcept C203014093 @default.
- W4313374518 hasConcept C2775983634 @default.
- W4313374518 hasConcept C2776914184 @default.
- W4313374518 hasConcept C2778690821 @default.
- W4313374518 hasConcept C2779134260 @default.
- W4313374518 hasConcept C2779244956 @default.
- W4313374518 hasConcept C2779559532 @default.
- W4313374518 hasConcept C2780467176 @default.
- W4313374518 hasConcept C3008058167 @default.
- W4313374518 hasConcept C524204448 @default.
- W4313374518 hasConcept C55493867 @default.
- W4313374518 hasConcept C60987743 @default.
- W4313374518 hasConcept C71924100 @default.
- W4313374518 hasConcept C86803240 @default.
- W4313374518 hasConcept C8891405 @default.
- W4313374518 hasConcept C89423630 @default.
- W4313374518 hasConceptScore W4313374518C104317684 @default.
- W4313374518 hasConceptScore W4313374518C136449434 @default.
- W4313374518 hasConceptScore W4313374518C142724271 @default.
- W4313374518 hasConceptScore W4313374518C170493617 @default.
- W4313374518 hasConceptScore W4313374518C202751555 @default.
- W4313374518 hasConceptScore W4313374518C203014093 @default.
- W4313374518 hasConceptScore W4313374518C2775983634 @default.
- W4313374518 hasConceptScore W4313374518C2776914184 @default.
- W4313374518 hasConceptScore W4313374518C2778690821 @default.
- W4313374518 hasConceptScore W4313374518C2779134260 @default.
- W4313374518 hasConceptScore W4313374518C2779244956 @default.
- W4313374518 hasConceptScore W4313374518C2779559532 @default.
- W4313374518 hasConceptScore W4313374518C2780467176 @default.
- W4313374518 hasConceptScore W4313374518C3008058167 @default.
- W4313374518 hasConceptScore W4313374518C524204448 @default.
- W4313374518 hasConceptScore W4313374518C55493867 @default.
- W4313374518 hasConceptScore W4313374518C60987743 @default.
- W4313374518 hasConceptScore W4313374518C71924100 @default.
- W4313374518 hasConceptScore W4313374518C86803240 @default.
- W4313374518 hasConceptScore W4313374518C8891405 @default.
- W4313374518 hasConceptScore W4313374518C89423630 @default.
- W4313374518 hasIssue "1_Supplement" @default.
- W4313374518 hasLocation W43133745181 @default.
- W4313374518 hasOpenAccess W4313374518 @default.
- W4313374518 hasPrimaryLocation W43133745181 @default.
- W4313374518 hasRelatedWork W1131976883 @default.
- W4313374518 hasRelatedWork W1939123102 @default.
- W4313374518 hasRelatedWork W2171475138 @default.
- W4313374518 hasRelatedWork W2266445187 @default.
- W4313374518 hasRelatedWork W2299552933 @default.
- W4313374518 hasRelatedWork W2811094328 @default.
- W4313374518 hasRelatedWork W2912114571 @default.
- W4313374518 hasRelatedWork W2913127801 @default.
- W4313374518 hasRelatedWork W4313374518 @default.
- W4313374518 hasRelatedWork W4313428151 @default.
- W4313374518 hasVolume "204" @default.
- W4313374518 isParatext "false" @default.
- W4313374518 isRetracted "false" @default.
- W4313374518 workType "article" @default.