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- W4313374519 abstract "Abstract Adipocyte-macrophage crosstalk plays a critical role in regulating adipose tissue microenvironment and causes chronic inflammation in the pathogenesis of obesity. Interleukin-29 (IL-29), a member of type 3 interferon family, plays a role in host defenses against microbes. The macrophage is one of the cellular sources of IL-29; however, the role of IL-29 in metabolic disorders is still unclear. We explored the function of IL-29 in the pathogenesis of obesity-induced inflammation and insulin resistance. We found that serum IL-29 level was significantly higher in obese patients. IL-29 upregulated IL-1β, IL-8, and monocyte chemoattractant protein-1 (MCP-1) expression and decreased glucose uptake and insulin sensitivity in human SGBS adipocytes through reducing glucose transporter 4 (GLUT4) and AKT signals. Inhibition of IL-29 could reduce inflammatory cytokine production in the macrophage-adipocyte co-culture system, which mimics an obese microenvironment. In vivo, IL-29 reduced insulin sensitivity and increased the number of peritoneal macrophages in high-fat diet (HFD)-induced obese mice. IL-29 increased M1/M2 macrophage ratio and enhanced MCP-1 expression in adipose tissues of HFD mice. Therefore, we have identified a critical role of IL-29 in obesity-induced inflammation and insulin resistance, and we conclude that IL-29 may be a novel candidate target for inhibiting obesity-induced inflammation and insulin resistance in patients with metabolic disorders." @default.
- W4313374519 created "2023-01-06" @default.
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- W4313374519 date "2020-05-01" @default.
- W4313374519 modified "2023-09-27" @default.
- W4313374519 title "The role of IL-29 in obesity-induced inflammation and insulin resistance" @default.
- W4313374519 doi "https://doi.org/10.4049/jimmunol.204.supp.59.35" @default.
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