Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313374584> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4313374584 endingPage "92.40" @default.
- W4313374584 startingPage "92.40" @default.
- W4313374584 abstract "Abstract Induction of adaptive immune responses in higher vertebrate species occur within organized lymphoid structures (e.g. lymph nodes, Peyer’s patches). It has been proposed that such structures emerged throughout evolutionary time with the goal to maximize encounters between antigens, antigens-presenting cells and B-T lymphocytes. Fish lack such structures and thus, it remains unknown how and where antigen-specific immunoglobulin responses are induced in these species. To understand how systemic immune responses are induced in teleost lymphoid organs, Rainbow Trout were immunized with several soluble protein antigens. Overall, our results identified the spleen as the major site for CD4+ T and IgM+ B cell proliferation in systemic lymphoid organs upon immunization. The proliferating splenic IgM+ B cells were frequently observed as clusters in the vicinity of melano-macrophage centers. Moreover, in these areas we observed aggregates of B and T lymphocytes with a loose organized structure reminiscent of the cellular architecture frequently associated with tertiary lymphoid organs. Laser dissection microdissection of these areas enabled us to evaluating the immunoglobulin IgM repertoires within these structures upon immunization. Critically, repertoire analysis identified processes of antigen-specific B cell clonal expansion. In conclusion, these data points to the previously unrecognized existence of primordial semi-organized lymphoid tissue in the spleen of teleost fish in which adaptive IgM immune responses are induced. Our findings provide strong evidence that the induction of antigen-specific immune responses in all bony vertebrates requires the formation of organized or semi-organized lymphoid structures." @default.
- W4313374584 created "2023-01-06" @default.
- W4313374584 creator A5011254550 @default.
- W4313374584 creator A5027123481 @default.
- W4313374584 creator A5064265355 @default.
- W4313374584 creator A5071581311 @default.
- W4313374584 creator A5075346685 @default.
- W4313374584 creator A5085004885 @default.
- W4313374584 date "2020-05-01" @default.
- W4313374584 modified "2023-10-06" @default.
- W4313374584 title "IDENTIFICATION OF PRIMORDIAL ORGANIZED LYMPHOID STRUCTURE IN THE SPLEEN OF TELEOST FISH" @default.
- W4313374584 doi "https://doi.org/10.4049/jimmunol.204.supp.92.40" @default.
- W4313374584 hasPublicationYear "2020" @default.
- W4313374584 type Work @default.
- W4313374584 citedByCount "1" @default.
- W4313374584 countsByYear W43133745842023 @default.
- W4313374584 crossrefType "journal-article" @default.
- W4313374584 hasAuthorship W4313374584A5011254550 @default.
- W4313374584 hasAuthorship W4313374584A5027123481 @default.
- W4313374584 hasAuthorship W4313374584A5064265355 @default.
- W4313374584 hasAuthorship W4313374584A5071581311 @default.
- W4313374584 hasAuthorship W4313374584A5075346685 @default.
- W4313374584 hasAuthorship W4313374584A5085004885 @default.
- W4313374584 hasConcept C147483822 @default.
- W4313374584 hasConcept C159654299 @default.
- W4313374584 hasConcept C181152851 @default.
- W4313374584 hasConcept C193419808 @default.
- W4313374584 hasConcept C203014093 @default.
- W4313374584 hasConcept C2778453870 @default.
- W4313374584 hasConcept C2780849966 @default.
- W4313374584 hasConcept C2780931953 @default.
- W4313374584 hasConcept C86803240 @default.
- W4313374584 hasConcept C8891405 @default.
- W4313374584 hasConceptScore W4313374584C147483822 @default.
- W4313374584 hasConceptScore W4313374584C159654299 @default.
- W4313374584 hasConceptScore W4313374584C181152851 @default.
- W4313374584 hasConceptScore W4313374584C193419808 @default.
- W4313374584 hasConceptScore W4313374584C203014093 @default.
- W4313374584 hasConceptScore W4313374584C2778453870 @default.
- W4313374584 hasConceptScore W4313374584C2780849966 @default.
- W4313374584 hasConceptScore W4313374584C2780931953 @default.
- W4313374584 hasConceptScore W4313374584C86803240 @default.
- W4313374584 hasConceptScore W4313374584C8891405 @default.
- W4313374584 hasIssue "1_Supplement" @default.
- W4313374584 hasLocation W43133745841 @default.
- W4313374584 hasOpenAccess W4313374584 @default.
- W4313374584 hasPrimaryLocation W43133745841 @default.
- W4313374584 hasRelatedWork W1922068371 @default.
- W4313374584 hasRelatedWork W2006557190 @default.
- W4313374584 hasRelatedWork W2028547021 @default.
- W4313374584 hasRelatedWork W2054816609 @default.
- W4313374584 hasRelatedWork W2081358646 @default.
- W4313374584 hasRelatedWork W2087539308 @default.
- W4313374584 hasRelatedWork W2220102944 @default.
- W4313374584 hasRelatedWork W2318322063 @default.
- W4313374584 hasRelatedWork W2523346616 @default.
- W4313374584 hasRelatedWork W579116757 @default.
- W4313374584 hasVolume "204" @default.
- W4313374584 isParatext "false" @default.
- W4313374584 isRetracted "false" @default.
- W4313374584 workType "article" @default.